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公开(公告)号：US08748387B2
公开(公告)日：2014-06-10
申请号：US13675893
申请日：2012-11-13
申请人： NoNO Inc.
发明人： Michael P. Belmares , Jonathan David Garman , Peter S. Lu , Michael W. Salter , Michael Tymianski
IPC分类号： C07K14/435 , A61K38/16 , A61K38/10 , A61K38/08
摘要： The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.
摘要翻译： 本发明提供可用于治疗疼痛的药剂。 一个示例性药剂包含一部分逆转录病毒Tat蛋白或由其组成。 一种这样的药剂是Tat-NR2B9c肽。 此肽以前已经被描述为通过抑制与NMDA受体和/或NOS的PSD95相互作用来抑制中风和类似条件的损伤作用的药剂。 本申请提供了显示Tat-NR2B9c肽有效缓解疼痛的数据。 疼痛缓解可以在低于抑制PSD-95与NMDAR或NOS相互作用所需剂量的肽剂量下获得。
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公开(公告)号：US20130137641A1
公开(公告)日：2013-05-30
申请号：US13675893
申请日：2012-11-13
申请人： NoNO Inc.
发明人： Michael P. Belmares , Jonathan David Garman , Peter S. Lu , Michael W. Salter , Michael Tymianski
摘要： The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.
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