公开(公告)号：US5166200A

公开(公告)日：1992-11-24

申请号：US683647

申请日：1991-04-11

申请人： Nobuaki Fujise ,  Yasushi Yamashita ,  Hiroaki Takaoka ,  Nobuyoshi Honda ,  Makoto Yoshihama

发明人： Nobuaki Fujise ,  Yasushi Yamashita ,  Hiroaki Takaoka ,  Nobuyoshi Honda ,  Makoto Yoshihama

IPC分类号： A61K31/565 ,  A61K31/56 ,  A61P13/02 ,  A61P15/00 ,  C07J1/00

CPC分类号： C07J1/0011

摘要： A remedy for endometriosis comprising, as an active ingredient, 14.alpha.-hydroxy-4-androstene-3,6,17-trione or an ester derivative thereof, can effectively treat endometriosis by the strong aromatase-inhibitory activity without giving serious side effects.

公开(公告)号：US06399744B1

公开(公告)日：2002-06-04

申请号：US08700519

申请日：1996-08-26

申请人： Masahiko Kinosaki ,  Kyoji Yamaguchi ,  Fumie Kobayashi ,  Masaaki Goto ,  Akihiko Murakami ,  Masatsugu Ueda ,  Yasushi Yamashita ,  Kanji Higashio

发明人： Masahiko Kinosaki ,  Kyoji Yamaguchi ,  Fumie Kobayashi ,  Masaaki Goto ,  Akihiko Murakami ,  Masatsugu Ueda ,  Yasushi Yamashita ,  Kanji Higashio

IPC分类号： C07K1400

CPC分类号： C07K14/4753 ,  A61K38/00

摘要： The present invention relates to a TCF mutant having a novel amino acid sequence which is obtained by mutagenesis of one or more amino acid between N-terminus and the first kringle of the amino acid sequence of native TCF and has lowered affinity to heparin and/or elevated biological activity. The present TCF mutant is prepared by gene manipulation of TCF. The TCF mutants of the present invention have proliferative activity and/or growth stimulative activity in hepatocyte and beneficial as a therapeutic agent for various hepatic diseases and an antitumor agent.

摘要翻译： 本发明涉及具有新氨基酸序列的TCF突变体，其通过在天然TCF的氨基酸序列的N末端与第一个三环体之间的一个或多个氨基酸的诱变获得，并且具有降低的对肝素和/或 升高的生物活性。 本发明的TCF突变体通过TCF的基因操作来制备。 本发明的TCF突变体在肝细胞中具有增殖活性和/或生长刺激活性，并且作为各种肝脏疾病和抗肿瘤剂的治疗剂是有益的。

公开(公告)号：US4924315A

公开(公告)日：1990-05-08

申请号：US316762

申请日：1989-02-28

申请人： Yasushi Yamashita

发明人： Yasushi Yamashita

IPC分类号： H04N9/00

CPC分类号： H04N7/012

摘要： The video signals outputted from a computer in a format of sequential scanning are memorized in a frame memory after being processed so that the isolated luminance signals do not exist in each horizontal scanning line. Furthermore, the video signals are read out from the frame memory in a format of interlaced scanning.

摘要翻译： 以顺序扫描的格式从计算机输出的视频信号在被处理之后被存储在帧存储器中，从而在每个水平扫描行中不存在孤立的亮度信号。 此外，以隔行扫描的格式从帧存储器中读出视频信号。