公开(公告)号：US20060014701A1

公开(公告)日：2006-01-19

申请号：US11218562

申请日：2005-09-06

申请人： Nobuo Ishiyama ,  Hirohide Ishige ,  Mitsuo Mimura ,  Tadashi Okuno ,  Kiyoharu Ukai ,  Takeshi Kiyofuji ,  Shinji Tauchi ,  Kiyoshi Inoguchi ,  Ping Huang ,  Gilda Loew ,  Linda Maki

发明人： Nobuo Ishiyama ,  Hirohide Ishige ,  Mitsuo Mimura ,  Tadashi Okuno ,  Kiyoharu Ukai ,  Takeshi Kiyofuji ,  Shinji Tauchi ,  Kiyoshi Inoguchi ,  Ping Huang ,  Gilda Loew ,  Linda Maki

IPC分类号： A61K38/04 ,  C07K5/04

CPC分类号： C07K5/06165 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06139

摘要： Disclosed are the novel compounds as growth hormone secretagogues represented by the structural Formula I: wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is —CO— or —SO2—, Y is: wherein n is an integer from 0-4, R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, R5 and R6 are independently selected from hydrogen, substituted or unsubstituted alkyl, or R5 and R6 or R4 and R5 are taken together to form substituted or unsubstituted alkylene, R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.

摘要翻译： 公开了由结构式I表示的生长激素促分泌素的新化合物：其中R 1是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的烷氧基，取代或未取代的芳基或取代的 或未取代的氨基，X是-CO-或-SO 2 - ，Y是：其中n是0-4的整数，R 4是氢，取代或未取代的 烷基，取代或未取代的环烷基，取代或未取代的芳基，R 5和R 6独立地选自氢，取代或未取代的烷基或R 5， R S和R 6或R 4和R 5一起形成取代或未取代的亚烷基，R 2 O， >是氢或取代或未取代的烷基，R 3是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的芳基，D是取代或未取代的 取代或未取代的烷氧基，或取代或未取代的烷硫基，*表示在人或动物中具有生长激素释放活性的不对称中心及其药学上可接受的盐和各异构体。