公开(公告)号：US20210000924A1

公开(公告)日：2021-01-07

申请号：US16977448

申请日：2019-03-07

Applicant: Northwestern University

Inventor： Omar K. Farha ,  Yijing Chen ,  Peng Li

IPC: A61K38/28 ,  A61K9/20

Abstract: Mesoporous zirconium metal-organic frameworks (MOFs) having insulin immobilized therein and methods of using the MOFs in insulin delivery are provided. The insulin-loaded metal-organic framework molecules include a porous zirconium metal-organic framework molecule and insulin molecules within pores of the porous zirconium metal-organic framework.

公开(公告)号：US11530404B2

公开(公告)日：2022-12-20

申请号：US16306563

申请日：2017-05-25

Applicant: Northwestern University

Inventor： Omar K. Farha ,  Peng Li ,  Justin A. Modica ,  Milan Mrksich ,  Joseph T. Hupp

IPC: C12N11/02 ,  C12N11/14 ,  C12P9/00 ,  A62D3/02 ,  C12N9/16 ,  C12N9/18 ,  A62D101/02 ,  A62D101/26

Abstract: Enzyme-immobilizing MOFs and methods for their use in enzymatically catalyzed reactions are provided. The MOFs are channel-type MOFs that present a hierarchical pore structure comprising a first set of large channels sized for enzyme immobilization and a second set of smaller channels running alongside of the large channels that remain enzyme-free and allow for reactant delivery to the enzymes and product expulsion from the larger channels.

公开(公告)号：US11666637B2

公开(公告)日：2023-06-06

申请号：US16977448

申请日：2019-03-07

Applicant: Northwestern University

Inventor： Omar K. Farha ,  Yijing Chen ,  Peng Li

IPC: A61K38/28 ,  A61K9/20

CPC classification number: A61K38/28 ,  A61K9/2013

Abstract: Mesoporous zirconium metal-organic frameworks (MOFs) having insulin immobilized therein and methods of using the MOFs in insulin delivery are provided. The insulin-loaded metal-organic framework molecules include a porous zirconium metal-organic framework molecule and insulin molecules within pores of the porous zirconium metal-organic framework.