公开(公告)号：US11286226B2

公开(公告)日：2022-03-29

申请号：US16137994

申请日：2018-09-21

Applicant: Northwestern University

Inventor： Regan James Thomson ,  Emily E. Robinson

IPC: C07C49/617 ,  C07C49/788 ,  C07C45/67 ,  C07C49/792 ,  C07D303/32 ,  C07D313/10 ,  C07C49/453 ,  C07C49/757 ,  C07C49/643

Abstract: Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.

公开(公告)号：US20190127306A1

公开(公告)日：2019-05-02

申请号：US16137994

申请日：2018-09-21

Applicant: Northwestern University

Inventor： Regan James Thomson ,  Emily E. Robinson

IPC: C07C49/788 ,  C07C45/67 ,  C07C49/792 ,  C07D303/32 ,  C07D313/10

Abstract: Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.