公开(公告)号：US20190127306A1

公开(公告)日：2019-05-02

申请号：US16137994

申请日：2018-09-21

Applicant: Northwestern University

Inventor： Regan James Thomson ,  Emily E. Robinson

IPC: C07C49/788 ,  C07C45/67 ,  C07C49/792 ,  C07D303/32 ,  C07D313/10

Abstract: Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.

公开(公告)号：US09529259B2

公开(公告)日：2016-12-27

申请号：US14827795

申请日：2015-08-17

Applicant: JSR CORPORATION

Inventor： Hayato Namai

IPC: G03F7/004 ,  G03F7/039 ,  G03F7/20 ,  G03F7/30 ,  G03F7/32 ,  C07C59/185 ,  C07C59/205 ,  C07C59/84 ,  C07C59/21 ,  C07C69/36 ,  C07C381/12 ,  C07D307/77 ,  C07D313/04 ,  C07D317/46 ,  C07D317/72 ,  C07D327/04 ,  C07D313/10 ,  C07D307/93 ,  C07D315/00 ,  C07C51/41 ,  C07C327/32 ,  C07C67/30 ,  C07C51/02 ,  C08F212/14 ,  G03F7/038 ,  C08F2/38 ,  C08F4/00 ,  C07C69/63 ,  C07C327/06 ,  C08F12/24

CPC classification number: G03F7/0045 ,  C07C51/02 ,  C07C51/41 ,  C07C59/185 ,  C07C59/205 ,  C07C59/21 ,  C07C59/84 ,  C07C67/30 ,  C07C69/36 ,  C07C69/63 ,  C07C327/06 ,  C07C327/32 ,  C07C381/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2603/74 ,  C07D307/77 ,  C07D307/93 ,  C07D313/04 ,  C07D313/10 ,  C07D315/00 ,  C07D317/46 ,  C07D317/72 ,  C07D327/04 ,  C08F2/38 ,  C08F4/00 ,  C08F12/24 ,  C08F212/14 ,  G03F7/004 ,  G03F7/0046 ,  G03F7/038 ,  G03F7/039 ,  G03F7/0397 ,  G03F7/2041 ,  G03F7/30 ,  G03F7/322 ,  G03F7/325 ,  C07C319/20 ,  C07C323/52

Abstract: A radiation-sensitive resin composition includes a polymer including a structural unit that includes an acid-labile group; and a compound represented by formula (1). R1 represents a monovalent organic group having 1 to 30 carbon atoms. L represents a single bond, an oxygen atom or a sulfur atom. M+ represents a monovalent radioactive ray-labile onium cation. The monovalent organic group represented by R1 is preferably a monovalent hydrocarbon group or a monovalent fluorinated hydrocarbon group, and L preferably represents a single bond. The monovalent organic group represented by R1 is preferably a monovalent hydrocarbon group, a monovalent fluorinated hydrocarbon group, a monovalent aliphatic heterocyclic group or a monovalent fluorinated aliphatic heterocyclic group, and L preferably represents an oxygen atom or a sulfur atom. The monovalent radioactive ray-labile onium cation represented by M+ is preferably represented by the formula (X).

Abstract translation: 辐射敏感性树脂组合物包括含有酸不稳定基团的结构单元的聚合物; 和由式（1）表示的化合物。 R1表示碳原子数为1〜30的一价有机基团。 L表示单键，氧原子或硫原子。 M +代表一价放射性不稳定鎓阳离子。 由R1表示的一价有机基团优选为一价烃基或一价氟化烃基，L优选表示单键。 由R1表示的一价有机基团优选为一价烃基，一价氟化烃基，一价脂族杂环基或一价含氟脂族杂环基，L优选表示氧原子或硫原子。 由M +表示的单价放射线不稳定鎓阳离子优选由式（X）表示。

公开(公告)号：US08486980B2

公开(公告)日：2013-07-16

申请号：US13057599

申请日：2009-08-06

Applicant: Arata Yanagisawa ,  Keiji Uehara ,  Masahiro Matsubara ,  Kimihisa Ueno ,  Michihiko Suzuki ,  Takeshi Kuboyama ,  Keisuke Yamamoto ,  Tomohiro Tamura

Inventor： Arata Yanagisawa ,  Keiji Uehara ,  Masahiro Matsubara ,  Kimihisa Ueno ,  Michihiko Suzuki ,  Takeshi Kuboyama ,  Keisuke Yamamoto ,  Tomohiro Tamura

IPC: A61K31/4245 ,  A61K31/335 ,  A61K31/4184 ,  A61K31/4188 ,  C07D271/07 ,  C07D313/10 ,  C07D235/00 ,  C07D235/04

CPC classification number: C07D471/04 ,  A61K31/335 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/4353 ,  A61K31/4409 ,  C07C255/34 ,  C07C255/44 ,  C07D235/08 ,  C07D235/16 ,  C07D257/04 ,  C07D403/10 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14

Abstract: Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

Abstract translation: 本发明提供具有PPARγ激动剂活性的三环化合物，其通式（I）表示，其中Z表示单键等，Y表示氢原子，任选具有取代基的低级烷基等， X表示氢原子等，A表示芳基等，B和C相同或不同，各自表示芳香族碳环等，R4-R9相同或不同，表示氢等， V表示单键等，R 10和R 11相同或不同，各自表示氢等，或其药学上可接受的盐等：

公开(公告)号：US08101761B2

公开(公告)日：2012-01-24

申请号：US12810886

申请日：2009-01-08

Applicant: Matthew William Carson ,  Michael Joseph Coghlan

Inventor： Matthew William Carson ,  Michael Joseph Coghlan

IPC: C07D455/03 ,  C07D313/10 ,  A61K31/4353

CPC classification number: C07D491/044

Abstract: The present invention provides Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with one or more pharmaceutically acceptable carriers, excipients, or diluents; and discloses methods for the treatment of inflammatory and immune disorders comprising administering to a patient in need thereof an effective amount of Compound (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供化合物（I）或其药学上可接受的盐; 包含化合物（I）与一种或多种药学上可接受的载体，赋形剂或稀释剂组合的药物组合物; 并公开了用于治疗炎症和免疫疾病的方法，包括向有需要的患者施用有效量的化合物（I）或其药学上可接受的盐。

公开(公告)号：US07956202B2

公开(公告)日：2011-06-07

申请号：US12632513

申请日：2009-12-07

Applicant: Gerardus Johannes Kemperman ,  Jacobus Johannes Maria Van Der Linden ,  Michael R. Reeder

Inventor： Gerardus Johannes Kemperman ,  Jacobus Johannes Maria Van Der Linden ,  Michael R. Reeder

IPC: C07D313/10

CPC classification number: C07D313/14 ,  C07D491/04

Abstract: Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.

Abstract translation: 公开了式（I）和（II）的新型氨基酸衍生物及其制备方法及其在制备反式-5-氯-2-甲基-2,3,3a，12b-四氢-1H- 二苯并[2,3：6,7]氧杂环庚烯并[4,5-c]吡咯。

公开(公告)号：US20100160293A1

公开(公告)日：2010-06-24

申请号：US11884392

申请日：2006-02-10

Applicant: Kakuji Tojo ,  Chiharu Kimura

Inventor： Kakuji Tojo ,  Chiharu Kimura

IPC: A61K31/55 ,  A61K31/4535 ,  A61K31/195 ,  A61K31/4178 ,  A61K31/335 ,  A61P27/02 ,  C07D409/08 ,  C07C63/00 ,  C07D405/06 ,  C07D313/10 ,  C07D223/14

CPC classification number: A61K9/0048 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/06 ,  A61K47/14 ,  A61K47/44

Abstract: An ophthalmic solid pharmaceutical preparation for external use is disclosed which can be used to continuously administer with ease a pharmacologically active agent to ocular local tissues. The pharmaceutical preparation is a solid pharmaceutical preparation containing a pharmacologically active ingredient in a base, which may comprise an oily base, and designed to be applied by being rubbed on the surface of the skin including the surface of either of the eyelids to deliver, through the skin of the eyelids, the pharmacologically active ingredient to the local tissues of the eye located on the backside of the eyelids.

Abstract translation: 公开了一种用于外用的眼用固体药物制剂，其可用于向眼部局部组织容易地连续施用药理活性剂。 药物制剂是在基质中含有药理活性成分的固体药物制剂，其可以包含油性基质，并且被设计为通过在皮肤表面上包括其中任何一种眼皮的表面进行摩擦来施用，以通过 眼皮的皮肤，药物活性成分到位于眼睑背面的眼睛的局部组织。

公开(公告)号：US20100160272A1

公开(公告)日：2010-06-24

申请号：US12641397

申请日：2009-12-18

Applicant: Thomas G. Gant ,  Manouchehr M. Shahbaz

Inventor： Thomas G. Gant ,  Manouchehr M. Shahbaz

IPC: A61K31/335 ,  C07D313/10 ,  A61K31/56 ,  A61P27/02

CPC classification number: C07D313/12

Abstract: The present invention relates to new oxepine modulators of H1 receptors and/or inhibitors of mast cell degranulation, pharmaceutical compositions thereof, and methods of use thereof.

Abstract translation: 本发明涉及H1受体的新型氧杂七度调节剂和/或肥大细胞脱粒抑制剂，其药物组合物及其使用方法。

公开(公告)号：US06949615B2

公开(公告)日：2005-09-27

申请号：US10181830

申请日：2001-10-31

Applicant: Keizo Inoue

Inventor： Keizo Inoue

IPC: C07C33/44 ,  C07C35/52 ,  C07C41/01 ,  C07C41/06 ,  C07C41/58 ,  C07C43/192 ,  C07C43/196 ,  C07C43/313 ,  C07C49/755 ,  C07D307/30 ,  C07D307/93 ,  C07D313/10 ,  C07D317/42 ,  C07D339/06 ,  C08F24/00 ,  G03F7/004 ,  G03F7/039 ,  C08F114/18

CPC classification number: C07C41/58 ,  C07C33/44 ,  C07C35/52 ,  C07C41/06 ,  C07C41/54 ,  C07C41/56 ,  C07C43/313 ,  C07C43/317 ,  C07C49/755 ,  C07C2602/42 ,  C07C2603/74 ,  C07D307/30 ,  C07D307/93 ,  C07D313/10 ,  C07D317/42 ,  C07D339/06 ,  C08F24/00 ,  G03F7/0046 ,  G03F7/0397 ,  C07C43/1786 ,  C07C43/196

Abstract: A monomer containing an electron-withdrawing group of the present invention is represented by following Formula (a), (b) or (c): wherein A1, A2, and A3 are each a ring; Ra, Rb, Rc, and Ru are the same or different and are each a hydrogen atom or organic group; at least one of Rs, Rw and Rv, at least one of Rt and Rw1, and at least one of the two Rw2s are each an electron-withdrawing group, and the others are each a hydrogen atom or organic group; W1 is a single bond or linkage group; and n denotes an integer of 2 to 25, where at least two of Ra, Rb, Rc, Rs, Rt, Ru, Rv, Rw, Rw1, Rw2, W1, and carbon atoms constituting ring A1, carbon atoms constituting ring A2, and carbon atoms constituting ring A3 may be combined to form a ring, respectively. The electron-withdrawing groups in Rs, Rt, Rv, Rw, Rw1, and Rw2 are, for example, groups each containing a fluorine atom. The monomer is useful as a raw material for photoresist polymeric compounds.

Abstract translation: 含有本发明吸电子基团的单体由下式（a），（b）或（c）表示：其中A 1，A 2， 和A <3>各自为环; R a，R b，R c和R u相同或不同，各自为氢 原子或有机基团; R 0和R 2中的至少一个，R 0和R 2中的至少一个，R 0和R 2， SUP> w1，并且两个R 2 w 2中的至少一个各自为吸电子基团，其余各自为氢原子或有机基团; W 1是单键或连接基团; n表示2〜25的整数，其中R a，R b，R b，R c，R i，R b， R 1，R 2，R 2，R 2，R 2，R 2，R 2，R 2， W 2，W 1，和构成环A 1的碳原子，构成环A 2的碳原子， 并且构成环A 3的碳原子可以分别结合形成环。 R“，”R“，”R“，”R“，”R“，”R“中的吸电子基团， w1，w2，...，w2都是例如各自含有氟原子的基团。 该单体可用作光致抗蚀剂聚合物的原料。

公开(公告)号：US10781198B2

公开(公告)日：2020-09-22

申请号：US16003497

申请日：2018-06-08

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Tatsuro Masuyama ,  Hiromu Nakamura ,  Koji Ichikawa

IPC: G03F7/039 ,  C07D313/10 ,  C08F220/68 ,  G03F7/004 ,  G03F7/30 ,  G03F7/16 ,  G03F7/20 ,  G03F7/38

Abstract: A compound represented by the formula (I): wherein the values of R1, R2, R3, Ar and X1 in formula (I) are defined in the specification.

公开(公告)号：US09643946B2

公开(公告)日：2017-05-09

申请号：US14771049

申请日：2014-02-28

Applicant: SK CHEMICALS CO., LTD.

Inventor： Ju Young Lee ,  Jeong A Lee ,  Jaeseung Ahn ,  Je Ho Ryu ,  Min-Young Han ,  Taekyung Yoo ,  Joon Ho Sa ,  Jae-Sun Kim ,  Jeongmin Seo

IPC: C07D307/80 ,  C07D313/10 ,  C07D335/02 ,  C07D405/12 ,  C07D239/70 ,  C07D307/20 ,  C07C317/18 ,  C07C229/46 ,  C07C59/72 ,  C07D223/20 ,  C07D311/80 ,  C07D313/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

CPC classification number: C07D307/80 ,  C07C59/72 ,  C07C229/46 ,  C07C317/18 ,  C07C2601/02 ,  C07C2603/26 ,  C07C2603/32 ,  C07D223/20 ,  C07D239/70 ,  C07D307/20 ,  C07D311/80 ,  C07D313/10 ,  C07D313/12 ,  C07D335/02 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12

Abstract: The present invention relates to: a compound selected from the group consisting of a tricyclic compound having the structure of formula I, a pharmaceutically acceptable salt, an isomer, a solvate and a precursor thereof; and a use thereof. The compound effectively controls GPR40, and thus, can be effectively used for the prophylaxis or treatment of diseases associated with GPR40, for example, diabetes and many other diseases.