公开(公告)号：US20250034108A1

公开(公告)日：2025-01-30

申请号：US18764471

申请日：2024-07-05

Applicant: NOVARTIS AG

Inventor： Robert Francis DAY ,  Hatice Belgin GULGEZE EFTHYMIOU ,  Adam FRIEDMAN ,  Tyler HARRISON ,  Jay Francis LARROW ,  Yunshan PENG ,  Nichola SMITH ,  Haihao TANG ,  Yanxiang WU ,  Sandra Marie KING ,  Sii Hong LAU ,  Tajesh PATEL

IPC: C07D401/04 ,  A61K31/41 ,  A61K31/4439 ,  C07D257/04

Abstract: The present disclosure relates to sulfonamide compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.

公开(公告)号：US20230089867A1

公开(公告)日：2023-03-23

申请号：US17296895

申请日：2019-11-26

Applicant: Novartis AG

Inventor： Christopher BECKER ,  Brian Addison DECHRISTOPHER ,  Alec Nathanson FLYER ,  Adam FRIEDMAN ,  Christian GAMPE ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Tyler HARRISON ,  Qian LIU ,  Eugene Yuejin LIU, I ,  Justin Yik Ching MAO ,  Lauren Gilchrist MONOVICH ,  Tajesh Jayprakash PATEL ,  Carina Cristina SANCHEZ ,  Liansheng SU ,  Lihua YANG ,  Rui ZHENG

IPC: C07K7/56

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6′, R7, R7′, R8, R9, R9′, R10, R11, R12, and n are described herein.