-
公开(公告)号:US20250034108A1
公开(公告)日:2025-01-30
申请号:US18764471
申请日:2024-07-05
Applicant: NOVARTIS AG
Inventor: Robert Francis DAY , Hatice Belgin GULGEZE EFTHYMIOU , Adam FRIEDMAN , Tyler HARRISON , Jay Francis LARROW , Yunshan PENG , Nichola SMITH , Haihao TANG , Yanxiang WU , Sandra Marie KING , Sii Hong LAU , Tajesh PATEL
IPC: C07D401/04 , A61K31/41 , A61K31/4439 , C07D257/04
Abstract: The present disclosure relates to sulfonamide compounds, the use thereof for modulating the sodium channel Nav1.5 and methods of treating or preventing diseases, disorders, or conditions using the same.
-
公开(公告)号:US20230089867A1
公开(公告)日:2023-03-23
申请号:US17296895
申请日:2019-11-26
Applicant: Novartis AG
Inventor: Christopher BECKER , Brian Addison DECHRISTOPHER , Alec Nathanson FLYER , Adam FRIEDMAN , Christian GAMPE , Andrei Alexandrovich GOLOSOV , Philipp GROSCHE , Tyler HARRISON , Qian LIU , Eugene Yuejin LIU, I , Justin Yik Ching MAO , Lauren Gilchrist MONOVICH , Tajesh Jayprakash PATEL , Carina Cristina SANCHEZ , Liansheng SU , Lihua YANG , Rui ZHENG
IPC: C07K7/56
Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6′, R7, R7′, R8, R9, R9′, R10, R11, R12, and n are described herein.
-