公开(公告)号：US20200164024A1

公开(公告)日：2020-05-28

申请号：US16695843

申请日：2019-11-26

申请人： NOVARTIS AG

发明人： Karin BRINER ,  Brian Addison DECHRISTOPHER ,  Alec Nathanson FLYER ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Eugene Yuejin LIU ,  Justin Yik Ching MAO ,  Lauren Gilchrist MONOVICH ,  Tajesh Jayprakash PATEL ,  Carina Cristina SANCHEZ ,  Liansheng SU ,  Lihua YANG ,  Rui ZHENG

IPC分类号： A61K38/12 ,  A61K45/06 ,  C07K5/12

摘要： The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

公开(公告)号：US20220024981A1

公开(公告)日：2022-01-27

申请号：US17296679

申请日：2019-11-26

申请人： Novartis AG

发明人： Alec Nathanson FLYER ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Ian LEWIS ,  Eugene Yuejin LIU ,  Andreas MARZINZIK ,  Lauren Gilchrist MONOVICH ,  Johannes OTTL ,  Tajesh Jayprakash PATEL ,  Patrick Crawford REID ,  Mohindra SEEPERSAUD

IPC分类号： C07K7/64 ,  A61K38/12 ,  A61K45/06

摘要： The disclosure relates to inhibitors of PCSK9 useful in the treatment of lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 are described herein.

公开(公告)号：US20230089867A1

公开(公告)日：2023-03-23

申请号：US17296895

申请日：2019-11-26

申请人： Novartis AG

发明人： Christopher BECKER ,  Brian Addison DECHRISTOPHER ,  Alec Nathanson FLYER ,  Adam FRIEDMAN ,  Christian GAMPE ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Tyler HARRISON ,  Qian LIU ,  Eugene Yuejin LIU, I ,  Justin Yik Ching MAO ,  Lauren Gilchrist MONOVICH ,  Tajesh Jayprakash PATEL ,  Carina Cristina SANCHEZ ,  Liansheng SU ,  Lihua YANG ,  Rui ZHENG

IPC分类号： C07K7/56

摘要： The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6′, R7, R7′, R8, R9, R9′, R10, R11, R12, and n are described herein.

公开(公告)号：US20210252103A1

公开(公告)日：2021-08-19

申请号：US17200471

申请日：2021-03-12

申请人： NOVARTIS AG

发明人： Karin BRINER ,  Brian Addison DECHRISTOPHER ,  Alec Nathanson FLYER ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Eugene Yuejin LIU ,  Justin Yik Ching MAO ,  Lauren Gilchrist MONOVICH ,  Tajesh Jayprakash PATEL ,  Liansheng SU ,  Lihua YANG ,  Rui ZHENG

IPC分类号： A61K38/12 ,  A61K45/06 ,  C07K5/12

摘要： The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.

公开(公告)号：US20160178610A1

公开(公告)日：2016-06-23

申请号：US14910590

申请日：2014-08-05

申请人： FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH ,  NOVARTIS AG ,  IRM LLC

发明人： Marc BUEHLER ,  Loren MIRAGLIA ,  Lauren Gilchrist MONOVICH ,  Anthony ORTH ,  Buu TU

IPC分类号： G01N33/50 ,  A61K31/496

CPC分类号： G01N33/502 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/496 ,  A61K31/713 ,  C12N5/0619 ,  C12N2501/38 ,  C12N2501/998 ,  C12N2506/45 ,  G01N33/5008

摘要： The present application provides a screening method for compounds useful for the treatment of Friedreich's ataxia, and a method for the treatment of Friedreich's ataxia.

摘要翻译： 本申请提供了用于治疗弗里德赖希共济失调的化合物的筛选方法，以及用于治疗弗里德赖希共济失调的方法。