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公开(公告)号：US20200165322A1
公开(公告)日：2020-05-28
申请号：US16716137
申请日：2019-12-16
Applicant: Novartis AG
Inventor： Kathrin Tissot , Stefan Ewert , Adrian Auf Der Maur , Alcide Barberis , Dominik Escher
Abstract: Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
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