公开(公告)号：US20210101902A1

公开(公告)日：2021-04-08

申请号：US17124346

申请日：2020-12-16

Applicant: NOVARTIS AG

Inventor： Phillip ALPER ,  Jonathan DEANE ,  Songchun JIANG ,  Tao JIANG ,  Thomas KNOEPFEL ,  Pierre-Yves MICHELLYS ,  Daniel MUTNICK ,  Wei PEI ,  Peter SYKA ,  Guobao ZHANG ,  Yi ZHANG

IPC: C07D471/04 ,  A61P17/06 ,  A61P1/16 ,  A61P37/06 ,  A61P19/02 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06

Abstract: The invention disclosed herein relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl compounds and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridinyl compounds of Formula (A), pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of autoimmune diseases.

公开(公告)号：US20190211009A1

公开(公告)日：2019-07-11

申请号：US16330820

申请日：2017-09-06

Applicant: Novartis AG

Inventor： Phillip Alper ,  Jonathan DEANE ,  Songchun JIANG ,  Tao JIANG ,  Thomas KNOEPFEL ,  Pierre-Yves MICHELLYS ,  Daniel MUTNICK ,  Wei PEI ,  Peter SYKA ,  Guobao ZHANG ,  YI ZHANG

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61K45/06 ,  A61P37/06 ,  A61P19/02 ,  A61P17/06 ,  A61P1/16

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61P1/16 ,  A61P17/06 ,  A61P19/02 ,  A61P37/06

Abstract: The invention disclosed herein relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl compounds and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridinyl compounds of Formula (A), pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of autoimmune diseases.

公开(公告)号：US20240376099A1

公开(公告)日：2024-11-14

申请号：US18678198

申请日：2024-05-30

Applicant: Novartis AG

Inventor： Phillip ALPER ,  Jonathan DEANE ,  Songchun JIANG ,  Tao JIANG ,  Thomas KNOEPFEL ,  Pierre-Yves MICHELLYS ,  Daniel MUTNICK ,  Wei PEI ,  Peter SYKA ,  Guobao ZHANG ,  Yi ZHANG

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61P1/16 ,  A61P17/06 ,  A61P19/02 ,  A61P37/06

Abstract: The invention disclosed herein relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl compounds and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridinyl compounds of Formula (A), pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of autoimmune diseases.

公开(公告)号：US20170217897A1

公开(公告)日：2017-08-03

申请号：US15500870

申请日：2015-08-03

Applicant: Zhigan JIANG ,  Jianhua XIA ,  Haiying HE ,  NOVARTIS AG

Inventor： Javier de Vicente FIDALGO ,  Haiying HE ,  Cheng HU ,  Zhigan JIANG ,  Xiaolin LI ,  Peichao LU ,  Wosenu MERGO ,  Daniel MUTNICK ,  Folkert RECK ,  Alexey RIVKIN ,  Colin Keith SKEPPER ,  Xiaojing Michael WANG ,  Jianhua XIA ,  Yongjin XU

IPC: C07D215/38 ,  A61K31/4709 ,  A61K31/496 ,  C07D401/14 ,  C07D413/14 ,  C07D419/14 ,  C07D405/14 ,  C07D471/04 ,  C07D498/10 ,  A61K31/5377 ,  A61K31/5386 ,  C07D487/10 ,  C07D471/10 ,  A61K45/06 ,  C07D401/04

CPC classification number: C07D215/38 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/22 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  Y02A50/406 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.