公开(公告)号：US20230416407A1

公开(公告)日：2023-12-28

申请号：US18197190

申请日：2023-05-15

Applicant: Novartis AG

Inventor： Regis CEBE ,  Stephane OLLAND ,  David Langdon YOWE

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61K39/39591 ,  C07K16/2863 ,  A61K2039/505

Abstract: The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

公开(公告)号：US20200087392A1

公开(公告)日：2020-03-19

申请号：US15749775

申请日：2016-08-02

Applicant: NOVARTIS AG

Inventor： Brian BOETTCHER ,  Shari Lynn CAPLAN ,  Regis CEBE ,  Guochun LI ,  John A TARASZKA ,  Fangmin XU ,  David Langdon YOWE

IPC: C07K16/28 ,  A61P3/00

Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

公开(公告)号：US20220162300A1

公开(公告)日：2022-05-26

申请号：US17539335

申请日：2021-12-01

Applicant: Novartis AG

Inventor： Brian BOETTCHER ,  Shari Lynn CAPLAN ,  Regis CEBE ,  Guochun LI ,  John A. TARASZKA ,  Fangmin XU ,  David Langdon YOWE

IPC: C07K16/28 ,  A61P3/00

Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

公开(公告)号：US20190040153A1

公开(公告)日：2019-02-07

申请号：US15890302

申请日：2018-02-06

Applicant: Novartis AG

Inventor： Regis CEBE ,  Stephane OLLAND ,  David Langdon YOWE

IPC: C07K16/40

Abstract: The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.