公开(公告)号：US20220162300A1

公开(公告)日：2022-05-26

申请号：US17539335

申请日：2021-12-01

Applicant: Novartis AG

Inventor： Brian BOETTCHER ,  Shari Lynn CAPLAN ,  Regis CEBE ,  Guochun LI ,  John A. TARASZKA ,  Fangmin XU ,  David Langdon YOWE

IPC: C07K16/28 ,  A61P3/00

Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

公开(公告)号：US20190071488A1

公开(公告)日：2019-03-07

申请号：US16183262

申请日：2018-11-07

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K45/06 ,  A61K39/42

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20230399382A1

公开(公告)日：2023-12-14

申请号：US18186064

申请日：2023-03-17

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K39/42 ,  A61K45/06 ,  A61K9/19

CPC classification number: C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  A61K9/19 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/24

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20200087392A1

公开(公告)日：2020-03-19

申请号：US15749775

申请日：2016-08-02

Applicant: NOVARTIS AG

Inventor： Brian BOETTCHER ,  Shari Lynn CAPLAN ,  Regis CEBE ,  Guochun LI ,  John A TARASZKA ,  Fangmin XU ,  David Langdon YOWE

IPC: C07K16/28 ,  A61P3/00

Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

公开(公告)号：US20250051423A1

公开(公告)日：2025-02-13

申请号：US18780282

申请日：2024-07-22

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K9/19 ,  A61K39/42 ,  A61K45/06

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20180079799A1

公开(公告)日：2018-03-22

申请号：US15829115

申请日：2017-12-01

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K45/06 ,  A61K39/42

CPC classification number: C07K16/084 ,  A61K9/19 ,  A61K39/42 ,  A61K45/06 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.