公开(公告)号：US20220348651A1

公开(公告)日：2022-11-03

申请号：US17642763

申请日：2020-09-17

Applicant: Novartis AG

Inventor： Michael DiDonato ,  Mirek Dostalek ,  Christoph Erkel ,  Javier Estrada Diez ,  Anna Galkin ,  Scott Martin Glaser ,  Klaus Felix Hartlepp ,  Yong Jia ,  Deborah A. Knee ,  Alexandra Kraus ,  Christian Cho-Hua Lee ,  Luigi Manenti ,  Sarah Michelle Rue ,  Jian Shi ,  Xenia Karola Wezler ,  Gabrielle Wong

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30

Abstract: Provided herein are methods of treating cancer using an antibody or antigen-binding fragments thereof that specifically bind to human ENTPD2 protein, and compositions comprising these antibodies or antigen-binding fragments for use in the treatment of cancer. The present invention also relates to combination therapies comprising an anti-human ENTPD2 antibody or antigen binding fragment and at least one additional therapeutic agent, and methods of using these combination therapies.

公开(公告)号：US20220340685A1

公开(公告)日：2022-10-27

申请号：US17642766

申请日：2020-09-17

Applicant: Novartis AG

Inventor： Michael DiDonato ,  Mirek Dostalek ,  Christoph Erkel ,  Javier Estrada Diez ,  Anna Galkin ,  Scott Martin Glaser ,  Klaus Felix Hartlepp ,  Yong Jia ,  Deborah A. Knee ,  Alexandra Kraus ,  Christian Cho-Hua Lee ,  Luigi Manenti ,  Sarah Michelle Rue ,  Jian Shi ,  Xenia Karola Wezler ,  Gabrielle Wong

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/22 ,  A61P35/00

Abstract: Provided herein are combinations comprising an antibody or antigen-binding fragment thereof, e.g., a monoclonal antibody or antigen binding fragment thereof, that specifically binds to ENTPD2 (e.g., human ENTPD2 protein), and an antibody or antigen-binding fragment thereof, e.g., a monoclonal antibody or antigen binding fragment thereof, that specifically binds to CD73 (e.g., human CD73 protein), and methods of using these combinations.

公开(公告)号：US10662247B2

公开(公告)日：2020-05-26

申请号：US15517867

申请日：2015-10-08

Applicant: NOVARTIS AG

Inventor： Jennifer Brogdon ,  Daniela Cipolletta ,  Glenn Dranoff ,  Deborah A. Knee ,  Fei Wang

IPC: C07K16/28 ,  A61K39/00 ,  A61K45/06

Abstract: The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors; as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.