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公开(公告)号：US20220340685A1
公开(公告)日：2022-10-27
申请号：US17642766
申请日：2020-09-17
Applicant: Novartis AG
Inventor： Michael DiDonato , Mirek Dostalek , Christoph Erkel , Javier Estrada Diez , Anna Galkin , Scott Martin Glaser , Klaus Felix Hartlepp , Yong Jia , Deborah A. Knee , Alexandra Kraus , Christian Cho-Hua Lee , Luigi Manenti , Sarah Michelle Rue , Jian Shi , Xenia Karola Wezler , Gabrielle Wong
Abstract: Provided herein are combinations comprising an antibody or antigen-binding fragment thereof, e.g., a monoclonal antibody or antigen binding fragment thereof, that specifically binds to ENTPD2 (e.g., human ENTPD2 protein), and an antibody or antigen-binding fragment thereof, e.g., a monoclonal antibody or antigen binding fragment thereof, that specifically binds to CD73 (e.g., human CD73 protein), and methods of using these combinations.
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公开(公告)号：US11930837B2
公开(公告)日：2024-03-19
申请号：US17403710
申请日：2021-08-16
Applicant: NOVARTIS AG
Inventor： Yaiza Diaz-De-Durana , Michael DiDonato , Christophe Filippi , Shelly Meeusen , Glen Spraggon
IPC: A61K38/20 , A23L7/10 , A23L7/104 , B02B1/04 , B02C4/06 , B02C4/16 , B02C9/00 , B02C23/18 , B02C23/40 , C07K16/46 , B02C15/14
CPC classification number: A23L7/197 , A23L7/104 , A61K38/2013 , B02B1/04 , B02C4/06 , B02C4/16 , B02C9/00 , B02C23/18 , B02C23/40 , C07K16/46 , A23V2002/00 , B02C15/14
Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
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Patent Agency Ranking
公开(公告)号：US20220348651A1
公开(公告)日：2022-11-03
申请号：US17642763
申请日：2020-09-17
Applicant: Novartis AG
Inventor： Michael DiDonato , Mirek Dostalek , Christoph Erkel , Javier Estrada Diez , Anna Galkin , Scott Martin Glaser , Klaus Felix Hartlepp , Yong Jia , Deborah A. Knee , Alexandra Kraus , Christian Cho-Hua Lee , Luigi Manenti , Sarah Michelle Rue , Jian Shi , Xenia Karola Wezler , Gabrielle Wong
Abstract: Provided herein are methods of treating cancer using an antibody or antigen-binding fragments thereof that specifically bind to human ENTPD2 protein, and compositions comprising these antibodies or antigen-binding fragments for use in the treatment of cancer. The present invention also relates to combination therapies comprising an anti-human ENTPD2 antibody or antigen binding fragment and at least one additional therapeutic agent, and methods of using these combination therapies.
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公开(公告)号：US20220346415A1
公开(公告)日：2022-11-03
申请号：US17813232
申请日：2022-07-18
Applicant: NOVARTIS AG
Inventor： Yaiza Diaz-De-Durana , Michael DiDonato , Christophe Filippi , Shelly Meeusen , Glen Spraggon
IPC: A23L7/10 , A23L7/104 , A61K38/20 , B02B1/04 , B02C4/06 , B02C4/16 , B02C9/00 , B02C23/18 , B02C23/40 , C07K16/46
Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
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公开(公告)号：US11122825B2
公开(公告)日：2021-09-21
申请号：US16616138
申请日：2018-05-22
Applicant: NOVARTIS AG
Inventor： Yaiza Diaz-De-Durana , Michael DiDonato , Christophe Filippi , Shelly Meeusen , Glen Spraggon
IPC: A61K38/20 , A23L7/10 , A23L7/104 , B02C4/16 , B02C4/06 , B02C23/40 , B02B1/04 , B02C9/00 , B02C23/18 , C07K16/46 , B02C15/14
Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
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公开(公告)号：US12006354B2
公开(公告)日：2024-06-11
申请号：US16616318
申请日：2018-05-22
Applicant: NOVARTIS AG
Inventor： Jonathan Deane , Yaiza Diaz-De-Durana , Michael DiDonato , Christophe Filippi , Glen Spraggon
IPC: C07K14/55 , A61K38/20 , A61K39/395 , A61K47/68 , A61P35/00 , C07K16/08 , C07K16/10 , C07K19/00 , C12N5/071 , C12N5/0783 , A61K39/00 , A61K45/06
CPC classification number: C07K16/1027 , A61K38/2013 , A61K39/3955 , A61K47/6801 , A61P35/00 , C07K14/55 , C07K19/00 , C12N5/0636 , C12N5/0682 , A61K2039/505 , A61K45/06 , C07K2317/56 , C07K2317/565 , C07K2317/94 , C07K2319/30
Abstract: The present disclosure provides for IL2 engrafted into the CDR sequences of an antibody having preferred therapeutic profiles over molecules known and used in the clinic. In particular, the provided antibody cytokine engrafted protein compositions increase or maintain CD8+ T effector cells while reducing the activity of Treg cells. Additionally, provided compositions convey improved half-life, stability and producibility over recombinant human IL2 formulations such as Proleukin®.
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公开(公告)号：US20200270334A1
公开(公告)日：2020-08-27
申请号：US16616318
申请日：2018-05-22
Applicant: NOVARTIS AG
Inventor： Jonathan Deane , Yaiza Diaz-De-Durana , Michael DiDonato , Christophe Filippi , Glen Spraggon
IPC: C07K16/10 , C07K14/55 , C12N5/0783 , A61K39/395 , A61K45/06 , C12N5/071 , A61P35/00
Abstract: The present disclosure provides for IL2 engrafted into the CDR sequences of an antibody having preferred therapeutic profiles over molecules known and used in the clinic. In particular, the provided antibody cytokine engrafted protein compositions increase or maintain CD8+ T effector cells while reducing the activity of Treg cells. Additionally, provided compositions convey improved half-life, stability and produceability over recombinant human IL2 formulations such as Proleukin®.
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