公开(公告)号：US20240352122A1

公开(公告)日：2024-10-24

申请号：US18636746

申请日：2024-04-16

Applicant: Novartis AG

Inventor： Joseph Anthony D'ALESSIO ,  Claudia Judith KLINTER ,  Cornelia Anne MUNDT ,  Richard Vaughan NEWCOMBE ,  Tamás SCHWEIGHOFFER ,  Katharina WINKELBACH

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68

CPC classification number: C07K16/2803 ,  A61K45/06 ,  A61K47/68031 ,  A61K47/6851 ,  C07K2317/565 ,  C07K2317/92

Abstract: Disclosed herein are antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof that bind human CD48. Also disclosed are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof; and methods of making and using such pharmaceutical compositions for treating cancer in a patient in need of treatment.

公开(公告)号：US20230091510A1

公开(公告)日：2023-03-23

申请号：US17612280

申请日：2020-05-19

Applicant: Novartis AG

Inventor： Zhuoliang CHEN ,  Katsumasa NAKAJIMA ,  Matthew T. BURGER ,  Joseph Anthony D'ALESSIO ,  Eric MCNEILL ,  Mark G, PALMERO ,  Bing YU ,  Qiang ZHANG

IPC: A61K47/68 ,  A61K47/54 ,  A61K47/60 ,  A61K47/61 ,  A61P35/00 ,  C07K16/28 ,  C07K5/062

Abstract: Provided herein are linkers, linker-drug groups and anti-body-drug conjugates comprising hydrophilic groups.