公开(公告)号：US10774036B2

公开(公告)日：2020-09-15

申请号：US16472386

申请日：2017-12-20

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Tobias Kapferer ,  Hongyong Kim ,  Jie Ku ,  Kurt Laumen ,  Yunzhong Li ,  Wei Peng ,  Thomas Ruch ,  Thierry Schlama ,  Yao Yang

IPC: C07C227/06 ,  C07C229/36 ,  C12P41/00

Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

公开(公告)号：US20150045562A1

公开(公告)日：2015-02-12

申请号：US14384233

申请日：2013-03-22

Applicant: NOVARTIS AG

Inventor： Michael Crowe ,  Michael Foulkes ,  Giancarlo Francese ,  Dominique Grimler ,  Ernst Kuesters ,  Kurt Laumen ,  Yunzhong Li ,  Changxue Lin ,  Jovana Nazor ,  Thomas Ruch ,  Derek Smith ,  Shiwei Song ,  Shangjun Teng

IPC: C12P17/10 ,  C07D209/38 ,  C07D209/12 ,  C07D405/06

CPC classification number: C12P17/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/34 ,  C07D209/38 ,  C07D405/06 ,  C07D471/20 ,  C12N9/1096 ,  Y02P20/52

Abstract: The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1′R,3′S)-5,7′-dichloro-6′-fluoro-3′-methyl-2′,3′,4′,9′-tetrahydrospiro[indoline-3,1′-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof.

Abstract translation: 本发明涉及可用于制备螺旋体酮化合物的方法和中间体，例如（1'R，3'S）-5,7'-二氯-6'-氟-3'-甲基-2'，3'， 4'，9'-四氢螺[二氢吲哚-3,1'-吡啶并[3,4-b]吲哚] -2-酮及其盐和水合物和溶剂化物。