公开(公告)号：US11434192B2

公开(公告)日：2022-09-06

申请号：US16452452

申请日：2019-06-25

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC: C07C59/84 ,  C07C67/035 ,  C07C213/08 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C51/373

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US10774036B2

公开(公告)日：2020-09-15

申请号：US16472386

申请日：2017-12-20

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Tobias Kapferer ,  Hongyong Kim ,  Jie Ku ,  Kurt Laumen ,  Yunzhong Li ,  Wei Peng ,  Thomas Ruch ,  Thierry Schlama ,  Yao Yang

IPC: C07C227/06 ,  C07C229/36 ,  C12P41/00

Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

公开(公告)号：US10377697B2

公开(公告)日：2019-08-13

申请号：US15780957

申请日：2016-12-08

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC: C07C51/373 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C59/84 ,  C07C67/035

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.