公开(公告)号：US12180291B2

公开(公告)日：2024-12-31

申请号：US18164519

申请日：2023-02-03

Applicant: Novartis AG

Inventor： Steven Bender ,  Tracy Charlton ,  Anna Galkin ,  Bernhard Hubert Geierstanger ,  Scott Martin Glaser ,  Shailaja Kasibhatla ,  Mark Knuth ,  Sabine Rottmann ,  Sarah Rue ,  Glen Spraggon ,  Tetsuo Uno

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  A61P35/00

Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US11634497B2

公开(公告)日：2023-04-25

申请号：US16482173

申请日：2018-02-01

Applicant: NOVARTIS AG

Inventor： Steven Bender ,  Tracy Charlton ,  Anna Galkin ,  Bernhard Hubert Geierstanger ,  Scott Martin Glaser ,  Shailaja Kasibhatla ,  Mark Knuth ,  Sabine Rottmann ,  Sarah Rue ,  Glen Spraggon ,  Tetsuo Uno

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K39/00

Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.