公开(公告)号：US20240309084A1

公开(公告)日：2024-09-19

申请号：US18272702

申请日：2022-01-18

Applicant: Novartis AG

Inventor： Martin ALLAN ,  Jeffrey BAGDANOFF ,  David Weninger BARNES ,  John BLANKENSHIP ,  James BRADNER ,  Kevin CLAIRMONT ,  Brian GRANDA ,  Guido JUNGE ,  Thomas SMITH ,  Elisabetta TRAGGIAI ,  Max WARNCKE

IPC: C07K16/28 ,  A61K47/54 ,  A61K47/68 ,  C07K16/40

CPC classification number: C07K16/28 ,  A61K47/549 ,  A61K47/6849 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/62 ,  C07K2317/70

Abstract: The present disclosure features bifunctional compounds for the degradation of extracellular targets, as well as compositions and related methods thereof.

公开(公告)号：US20220356455A1

公开(公告)日：2022-11-10

申请号：US17261533

申请日：2019-07-17

Applicant: NOVARTIS AG

Inventor： Agostino CIRILLO ,  Hilmar EBERSBACH ,  Boerje HARALDSSON ,  Thomas HUBER ,  Guido JUNGE ,  Regina LINK ,  Max WARNCKE ,  Chao ZOU

IPC: C12N9/14 ,  A61K45/06

Abstract: The invention relates to design and therapeutic use of solubilized apyrase polypeptides, pharmaceuticals compositions, therapeutic uses and methods useful for preventing and treating tissue damage.