公开(公告)号：US20230279394A1

公开(公告)日：2023-09-07

申请号：US17786347

申请日：2020-12-16

Applicant: Novartis AG

Inventor： Muluken BELEW ,  Simone BONAZZI ,  James BRADNER ,  Artiom CERNIJENKO ,  Jennifer Stroka COBB ,  Natalie DALES ,  John Ryan KERRIGAN ,  Philip LAM ,  Hasnain Ahmed MALIK ,  Carsten RUSS ,  Frederic SIGOILLOT ,  Susan C. STEVENSON ,  Noel Marie-France THOMSEN ,  Pamela TING

IPC: C12N15/113 ,  C12N15/86 ,  C12N5/07 ,  A61P7/00

CPC classification number: C12N15/113 ,  A61P7/00 ,  C12N5/06 ,  C12N15/86 ,  C12N2310/20

Abstract: The present invention is directed to compositions and methods for the treatment of hemoglobinopathies.

公开(公告)号：US20240309084A1

公开(公告)日：2024-09-19

申请号：US18272702

申请日：2022-01-18

Applicant: Novartis AG

Inventor： Martin ALLAN ,  Jeffrey BAGDANOFF ,  David Weninger BARNES ,  John BLANKENSHIP ,  James BRADNER ,  Kevin CLAIRMONT ,  Brian GRANDA ,  Guido JUNGE ,  Thomas SMITH ,  Elisabetta TRAGGIAI ,  Max WARNCKE

IPC: C07K16/28 ,  A61K47/54 ,  A61K47/68 ,  C07K16/40

CPC classification number: C07K16/28 ,  A61K47/549 ,  A61K47/6849 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/62 ,  C07K2317/70

Abstract: The present disclosure features bifunctional compounds for the degradation of extracellular targets, as well as compositions and related methods thereof.