公开(公告)号：US20200299281A1

公开(公告)日：2020-09-24

申请号：US16088374

申请日：2017-03-27

Applicant: Novartis AG

Inventor： Fabrice Gallou ,  Michael PARMENTIER ,  Jianguang ZHOU ,  Pengfei GUO

IPC: C07D405/14 ,  C07D401/04 ,  C07D403/14 ,  C07C269/06 ,  C07D333/64 ,  C07C211/52 ,  C07D487/04 ,  C07D241/20

Abstract: The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.

公开(公告)号：US20220274966A1

公开(公告)日：2022-09-01

申请号：US17663285

申请日：2022-05-13

Applicant: Novartis AG

Inventor： Fabrice GALLOU ,  Michael PARMENTIER

IPC: C07D405/14 ,  C07B63/04

Abstract: The present invention is directed to methods for producing crystals or aggregates of organic compounds using a composition comprising a surfactant-water mixture, the organic compound and optionally an organic solvent as starting composition. This surfactant system enables the production of a high variety of different crystals and aggregates. The method is in particular suitable for obtaining crystals and aggregates optimized for isolation and purification during chemical synthesis processes.

公开(公告)号：US20200017482A1

公开(公告)日：2020-01-16

申请号：US16334970

申请日：2017-09-26

Applicant: Novartis AG

Inventor： Fabrice GALLOU ,  Michael PARMENTIER

IPC: C07D405/14 ,  C07B63/04

Abstract: The present invention is directed to methods for producing crystals or aggregates of organic compounds using a composition comprising a surfactant-water mixture, the organic compound and optionally an organic solvent as starting composition. This surfactant system enables the production of a high variety of different crystals and aggregates. The method is in particular suitable for obtaining crystals and aggregates optimized for isolation and purification during chemical synthesis processes.