公开(公告)号：US20240216513A1

公开(公告)日：2024-07-04

申请号：US18281732

申请日：2022-03-10

Applicant: Novartis AG

Inventor： Claire Adcock ,  Valerie Broennimann ,  Jiashun Cheng ,  Rohit Kumar Duvadie ,  Tanzina Fazal ,  Jinhai Gao ,  Fengfeng Guo ,  Robert Martin Grotzfeld ,  Christina Hebach ,  Gregory John Hollingworth ,  Darryl Brynley Jones ,  Alexei Karpov ,  Jialiang Li ,  Julien Lorber ,  Chester A. Metcalf, III ,  Walter Michael ,  Mark Gabriel Palermo ,  Scott Vaughan Plummer ,  James Harold Roache ,  Martin Sendzik ,  Ranny Mathew Thomas ,  Aimee Richardson Usera ,  Anna Vulpetti ,  Frederic Zecri ,  Liang Zhao ,  Thomas Zoller

IPC: A61K47/54 ,  A61K31/395 ,  A61K47/10 ,  A61P35/00

CPC classification number: A61K47/542 ,  A61K31/395 ,  A61K47/10 ,  A61P35/00

Abstract: Described herein are fatty acid-bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.