公开(公告)号：US20180030061A1

公开(公告)日：2018-02-01

申请号：US15729979

申请日：2017-10-11

Applicant: NOVARTIS AG

Inventor： Carole Pissot Soldermann ,  Jean Quancard ,  Achim Schlapbach ,  Oliver Simic ,  Marina Tintelnot-Blomley ,  Thomas Zoller

IPC: C07D487/04 ,  A61K31/5377 ,  A61K31/519

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

公开(公告)号：US11613543B2

公开(公告)日：2023-03-28

申请号：US16981059

申请日：2019-03-22

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Julien Lorber ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  A61K45/06

Abstract: The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20210002285A1

公开(公告)日：2021-01-07

申请号：US16981059

申请日：2019-03-22

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Julien Lorber ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: C07D487/04 ,  C07D519/00

Abstract: The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20210251996A1

公开(公告)日：2021-08-19

申请号：US16981208

申请日：2019-03-25

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: A61K31/519 ,  C07D519/00 ,  C07D487/04 ,  A61P35/00

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20240216513A1

公开(公告)日：2024-07-04

申请号：US18281732

申请日：2022-03-10

Applicant: Novartis AG

Inventor： Claire Adcock ,  Valerie Broennimann ,  Jiashun Cheng ,  Rohit Kumar Duvadie ,  Tanzina Fazal ,  Jinhai Gao ,  Fengfeng Guo ,  Robert Martin Grotzfeld ,  Christina Hebach ,  Gregory John Hollingworth ,  Darryl Brynley Jones ,  Alexei Karpov ,  Jialiang Li ,  Julien Lorber ,  Chester A. Metcalf, III ,  Walter Michael ,  Mark Gabriel Palermo ,  Scott Vaughan Plummer ,  James Harold Roache ,  Martin Sendzik ,  Ranny Mathew Thomas ,  Aimee Richardson Usera ,  Anna Vulpetti ,  Frederic Zecri ,  Liang Zhao ,  Thomas Zoller

IPC: A61K47/54 ,  A61K31/395 ,  A61K47/10 ,  A61P35/00

CPC classification number: A61K47/542 ,  A61K31/395 ,  A61K47/10 ,  A61P35/00

Abstract: Described herein are fatty acid-bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.

公开(公告)号：US11541056B2

公开(公告)日：2023-01-03

申请号：US16981208

申请日：2019-03-25

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: C07D519/00 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US10442808B2

公开(公告)日：2019-10-15

申请号：US15729979

申请日：2017-10-11

Applicant: NOVARTIS AG

Inventor： Carole Pissot Soldermann ,  Jean Quancard ,  Achim Schlapbach ,  Oliver Simic ,  Marina Tintelnot-Blomley ,  Thomas Zoller

IPC: A61K31/519 ,  A61K31/5377 ,  C07D487/04

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives according to Formula (I) which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.