公开(公告)号：US20250059181A1

公开(公告)日：2025-02-20

申请号：US18504244

申请日：2023-11-08

Applicant: Novartis AG

Inventor： Nigel Graham Cooke ,  Paulo Fernandes Gomes dos Santos ,  Nadege Graveleau ,  Christina Hebach ,  Klemens Högenauer ,  Gregory Hollingworth ,  Alexander Baxter Smith ,  Nicolas Soldermann ,  Frank Stowasser ,  Ross Sinclair Strang ,  Nicola Tufilli ,  Anette Von Matt ,  Romain Wolf ,  Frédéric Zecri

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/00

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

公开(公告)号：US20220267318A1

公开(公告)日：2022-08-25

申请号：US17399090

申请日：2021-08-11

Applicant: Novartis AG

Inventor： Nigel Graham Cooke ,  Paulo Fernandes Gomes Dos Santos ,  Nadege Graveleau ,  Christina Hebach ,  Klemens Hoegenauer ,  Gregory John Hollingworth ,  Alexander Baxter Smith ,  Nicolas Soldermann ,  Frank Stowasser ,  Ross Sinclair Strang ,  Nicola Tufilli ,  Anette von Matt ,  Romain Wolf ,  Frederic Zecri

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/519 ,  A61K31/5377

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

公开(公告)号：US11878973B2

公开(公告)日：2024-01-23

申请号：US17824407

申请日：2022-05-25

Applicant: NOVARTIS AG

Inventor： Vincent Bordas ,  Jvan Brun ,  Markus Furegati ,  Jacques Hamon ,  Jürgen Hans-Hermann Hinrichs ,  Philipp Holzer ,  Fatma Limam ,  Henrik Möbitz ,  Sandro Nocito ,  Simone Plattner ,  Niko Schmiedeberg ,  Joseph Schoepfer ,  Ross Sinclair Strang ,  Frédéric Zecri

IPC: C07D413/14 ,  C07D401/14 ,  C07D405/14

CPC classification number: C07D413/14 ,  C07D401/14 ,  C07D405/14 ,  C07B2200/13

Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):




wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

公开(公告)号：US20190218217A1

公开(公告)日：2019-07-18

申请号：US16367525

申请日：2019-03-28

Applicant: Novartis AG

Inventor： Nigel Graham Cooke ,  Paulo Fernandes Gomes Dos Santos ,  Nadege Graveleau ,  Christina Hebach ,  Klemens Hoegenauer ,  Gregory John Hollingworth ,  Alexander Baxter Smith ,  Nicolas Soldermann ,  Frank Stowasser ,  Ross Sinclair Strang ,  Nicola Tufilli ,  Anette von Matt ,  Romain Wolf ,  Frederic Zecri

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  C07B2200/05

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

公开(公告)号：US20190040061A1

公开(公告)日：2019-02-07

申请号：US16163106

申请日：2018-10-17

Applicant: Novartis AG

Inventor： Nigel Graham Cooke ,  Paulo Fernandes Gomes Dos Santos ,  Nadege Graveleau ,  Christina Hebach ,  Klemens Hoegenauer ,  Gregory John Hollingworth ,  Alexander Baxter Smith ,  Nicolas Soldermann ,  Frank Stowasser ,  Ross Sinclair Strang ,  Nicola Tufilli ,  Anette von Matt ,  Romain Wolf ,  Frederic Zecri

IPC: C07D471/04 ,  A61K31/5377 ,  A61K31/519

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

公开(公告)号：US20180265509A1

公开(公告)日：2018-09-20

申请号：US15993051

申请日：2018-05-30

Applicant: Novartis AG

Inventor： Nigel Graham Cooke ,  Paulo Fernandes Gomes Dos Santos ,  Nadege Graveleau ,  Christina Hebach ,  Klemens Hoegenauer ,  Gregory John Hollingworth ,  Alexander Baxter Smith ,  Nicolas Soldermann ,  Frank Stowasser ,  Ross Sinclair Strang ,  Nicola Tufilli ,  Anette von Matt ,  Romain Wolf ,  Frederic Zecri

IPC: C07D471/04 ,  A61K31/5377 ,  A61K31/519

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  C07B2200/05

Abstract: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.