公开(公告)号：US11827704B2

公开(公告)日：2023-11-28

申请号：US16925980

申请日：2020-07-10

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： G01N33/574 ,  C07K16/28 ,  G01N33/566 ,  G01N33/68 ,  A61K45/06 ,  C07K16/30

CPC分类号： C07K16/2818 ,  A61K45/06 ,  C07K16/2896 ,  C07K16/30 ,  G01N33/566 ,  G01N33/57484 ,  G01N33/6854 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70596 ,  Y02A50/30

摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US20190000944A1

公开(公告)日：2019-01-03

申请号：US16065387

申请日：2016-12-21

申请人： Jennifer Brogdon ,  Hwai Wen Chang ,  Boris Engels ,  Gordon James Freeman ,  Gerhard Johann Frey ,  Jennifer Marie Mataraza ,  Reshma Singh ,  Arlene Helen Sharpe ,  Novartis AG ,  The Trustees of the University of Pennsylvania ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Jennifer Brogdon ,  Hwai Wen Chang ,  Boris Engels ,  Gordon James Freeman ,  Gerhard Johann Frey ,  Jennifer Marie Mataraza ,  Reshma Singh ,  Arlene Helen Sharpe

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  A61K45/06

摘要： Provided are compositions for use in methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.

公开(公告)号：US20230000964A1

公开(公告)日：2023-01-05

申请号：US17811606

申请日：2022-07-11

申请人： Novartis AG ,  The Trustees of the University of Pennsylvania ,  Dana-Farber Cancer Institute, Inc. ,  President and Fellows of Harvard College

发明人： Jennifer Brogdon ,  Hwai Wen Chang ,  Boris Engels ,  Gordon James Freeman ,  Gerhard Johann Frey ,  Jennifer Marie Mataraza ,  Reshma Singh ,  Arlene Helen Sharpe

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06

摘要： Provided are compositions and methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.

公开(公告)号：US10851165B2

公开(公告)日：2020-12-01

申请号：US15900153

申请日：2018-02-20

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Gerhard Johann Frey ,  Hwai Wen Chang ,  Jennifer Marie Mataraza ,  Glenn Dranoff

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  A61N5/10 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US09683048B2

公开(公告)日：2017-06-20

申请号：US14604415

申请日：2015-01-23

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  G01N33/566 ,  G01N33/68 ,  A61K45/06

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  G01N33/57484 ,  G01N33/6854 ,  G01N2333/70596 ,  Y02A50/58

摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US20240343808A1

公开(公告)日：2024-10-17

申请号：US18392954

申请日：2023-12-21

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Gerhard Johann Frey ,  Hwai Wen Chang ,  Jennifer Marie Mataraza ,  Glenn Dranoff

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61N5/10 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K16/2827 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61N5/10 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70532

摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US20210284737A1

公开(公告)日：2021-09-16

申请号：US17078929

申请日：2020-10-23

申请人： NOVARTIS AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Gerhard Johann Frey ,  Hwai Wen Chang ,  Jennifer Marie Mataraza ,  Glenn Dranoff

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61N5/10 ,  C07K16/30 ,  G01N33/574

摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US20150210769A1

公开(公告)日：2015-07-30

申请号：US14604415

申请日：2015-01-23

申请人： Novartis AG ,  Dana-Farber Cancer Institute, Inc. ,  President and Fellows of Harvard College

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： C07K16/28 ,  G01N33/574 ,  A61K39/395

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  G01N33/57484 ,  G01N33/6854 ,  G01N2333/70596 ,  Y02A50/58

摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

摘要翻译： 公开了特异性结合PD-1的抗体分子。 抗PD-1抗体分子可用于治疗，预防和/或诊断癌性或感染性疾病和病症。

公开(公告)号：US10752687B2

公开(公告)日：2020-08-25

申请号：US15727456

申请日：2017-10-06

申请人： NOVARTIS AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： C07K16/28 ,  C07K16/30 ,  G01N33/566 ,  G01N33/68 ,  A61K45/06 ,  G01N33/574

摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US20180155427A1

公开(公告)日：2018-06-07

申请号：US15727456

申请日：2017-10-06

申请人： NOVARTIS AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： C07K16/28

摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.