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    SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF
    2.
    发明申请
    SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF 有权

    公开(公告)号：US20220002240A1

    公开(公告)日：2022-01-06

    申请号：US17353681

    申请日：2021-06-21

    申请人： NovoMedix, LLC

    发明人： Leah M. Fung ,  Kyle W. H. Chan ,  Cathy A. Swindlehurst ,  Robert W. Sullivan

    IPC分类号： C07C311/21 ,  A61K31/18 ,  A61K31/337 ,  A61K45/06

    摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorder

    Furanyl compounds and the use thereof
    4.
    发明授权
    Furanyl compounds and the use thereof 有权

    公开(公告)号：US09663483B2

    公开(公告)日：2017-05-30

    申请号：US14871552

    申请日：2015-09-30

    申请人： NovoMedix, LLC

    发明人： Leah M. Fung ,  Kyle W. H. Chan ,  Cathy A. Swindlehurst

    IPC分类号： A61K31/341 ,  A61K45/06 ,  C07D307/68

    CPC分类号： C07D307/68 ,  A61K31/341 ,  A61K45/06

    摘要： Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

    Furanyl compounds and the use thereof
    6.
    发明授权
    Furanyl compounds and the use thereof 有权
    呋喃基化合物及其用途

    公开(公告)号：US09149527B2

    公开(公告)日：2015-10-06

    申请号：US14250089

    申请日：2014-04-10

    申请人： NovoMedix, LLC

    发明人： Leah M. Fung ,  Kyle W. H. Chan ,  Cathy A. Swindlehurst

    IPC分类号： A61K31/341 ,  A61K45/06 ,  C07D307/68

    CPC分类号： C07D307/68 ,  A61K31/341 ,  A61K45/06

    摘要： Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

    摘要翻译： 本文提供取代的呋喃基化合物，包含化合物的药物组合物，其制备方法及其使用方法。 本文提供的化合物可用于治疗，预防和/或改善各种疾病，包括癌症和增殖性疾病。 在一个实施方案中，本文提供的化合物调节eIF4E活性。 在一个实施方案中，本文提供的化合物调节Hedgehog途径活性。 在一个实施方案中，本文提供的化合物与外科，放射治疗，免疫治疗和/或一种或多种另外的抗癌药物结合使用，用于治疗，预防和/或改善癌症和增殖性疾病。

    SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF
    8.
    发明申请
    SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF 审中-公开

    公开(公告)号：US20200062700A1

    公开(公告)日：2020-02-27

    申请号：US16674943

    申请日：2019-11-05

    申请人： NovoMedix, LLC

    发明人： Leah M. Fung ,  Kyle W. H. Chan ,  Cathy A. Swindlehurst ,  Robert W. Sullivan

    IPC分类号： C07C311/21 ,  A61K31/18 ,  A61K31/337 ,  A61K45/06

    摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

    Substituted biaryl sulfonamides and the use thereof
    9.
    发明授权
    Substituted biaryl sulfonamides and the use thereof 有权
    取代的联芳基磺酰胺及其用途

    公开(公告)号：US09156781B2

    公开(公告)日：2015-10-13

    申请号：US14092425

    申请日：2013-11-27

    申请人： NOVOMEDIX, LLC

    发明人： Leah M. Fung ,  Kyle W. H. Chan ,  Cathy A. Swindlehurst ,  Robert W. Sullivan

    IPC分类号： A61K31/18 ,  C07C311/21 ,  A61K31/337 ,  A61K45/06

    CPC分类号： C07C311/21 ,  A61K31/18 ,  A61K31/337 ,  A61K45/06

    摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

    摘要翻译： 本文提供取代的联芳基磺酰胺化合物，包含化合物的药物组合物，其制备方法及其用途。 本文提供的化合物可用于治疗，预防和/或改善各种疾病，包括癌症和增殖性疾病。 在一个实施方案中，本文提供的化合物调节蛋白质翻译的起始。 在一个实施方案中，本文提供的化合物与外科，放射治疗，免疫治疗和/或一种或多种另外的抗癌药物结合使用以治疗，预防和/或改善癌症和增殖性疾病。