公开(公告)号：US12037309B2

公开(公告)日：2024-07-16

申请号：US18385982

申请日：2023-11-01

申请人： Vector Vitale IP LLC

发明人： Peter Novak ,  Maxim Temnikov ,  Oleksandr Balakin

IPC分类号： C07C311/21 ,  A61P35/00

CPC分类号： C07C311/21 ,  A61P35/00

摘要： Novel 85Rb-enriched rubidium salt compounds of general formula 1, below and novel compounds of general formula 2, below. Compositions that contain at least one of the novel compounds and optionally further contain an antitumor drug. Methods that entail administering such compounds and compositions to treat cancer, optionally in combination with a conventional form of cancer therapy, such as chemotherapy and radiation treatment. When administered with a conventional form of cancer therapy, the compounds and compositions of the invention may be administered before, simultaneously with, or after administration of the conventional form of cancer therapy.

公开(公告)号：US11884612B2

公开(公告)日：2024-01-30

申请号：US16085243

申请日：2017-03-16

申请人： The Regents of the University of California

发明人： Lei Wang ,  Christian Hoppmann

IPC分类号： C07C311/21 ,  C07C313/02 ,  C07K1/107

CPC分类号： C07C311/21 ,  C07C313/02 ,  C07K1/1075

摘要： There are provided, inter alia, compositions and methods for covalently binding peptides to proteins.

公开(公告)号：US11827588B2

公开(公告)日：2023-11-28

申请号：US17696701

申请日：2022-03-16

申请人： Vector Vitale IP LLC

发明人： Peter Novak ,  Maxim Temnikov ,  Oleksandr Balakin

IPC分类号： C07C311/21 ,  A61P35/00

CPC分类号： C07C311/21 ,  A61P35/00

摘要： Novel 85Rb-enriched rubidium salt compounds of general formula 1, below and novel compounds of general formula 2, below. Compositions that contain at least one of the novel compounds and optionally further contain an antitumor drug. Methods that entail administering such compounds and compositions to treat cancer, optionally in combination with a conventional form of cancer therapy, such as chemotherapy and radiation treatment. When administered with a conventional form of cancer therapy, the compounds and compositions of the invention may be administered before, simultaneously with, or after administration of the conventional form of cancer therapy.

公开(公告)号：US20230212122A1

公开(公告)日：2023-07-06

申请号：US17927094

申请日：2021-05-25

申请人： The Regents of the University of Michigan

发明人： Nouri Neamati ,  Ding Xue ,  Yibin Xu

IPC分类号： C07D211/96 ,  C07D401/06 ,  C07D413/14 ,  C07D413/04 ,  C07D401/12 ,  C07C311/21 ,  C07D401/04

CPC分类号： C07D211/96 ,  C07D401/06 ,  C07D413/14 ,  C07D413/04 ,  C07D401/12 ,  C07C311/21 ,  C07D401/04

摘要： Mitochondrial targeting compounds for the treatment of cancer and other disorders associated with mitochondrial function, including diabetes, autoimmune diseases, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases and their preparation. The present invention is also directed to the pharmaceutical compositions and treatment methods, prodrugs based on those compounds and the use thereof.

公开(公告)号：US20190241511A1

公开(公告)日：2019-08-08

申请号：US16317492

申请日：2017-07-25

申请人： FRESENIUS KABI ONCOLOGY LTD.

发明人： Sridhar Reddy MALE ,  Saurabh UPADHYAY ,  Suneel Kumar SHARMA ,  Hrishikesh ACHARYA ,  Govind SINGH ,  Saswata LAHIRI ,  Walter CABRI

IPC分类号： C07C311/21 ,  C07C303/44 ,  A61P35/00

CPC分类号： C07C311/21 ,  A61P35/00 ,  C07B2200/13 ,  C07C303/40 ,  C07C303/44 ,  C07C311/37

摘要： The present invention relates to the polymorphic forms of Belinostat. The invention also relates to the process for the preparation of the polymorphic forms of Belinostat. This invention further relates to pharmaceutical composition of said polymorphic forms of Belinostat and use thereof in the treatment of a patient in need thereof.

公开(公告)号：US10040757B2

公开(公告)日：2018-08-07

申请号：US15434531

申请日：2017-02-16

申请人： NovoMedix, LLC

发明人： Leah M. Fung ,  Kyle W. H. Chan ,  Cathy A. Swindlehurst ,  Robert W. Sullivan

IPC分类号： A61K31/18 ,  C07C311/21 ,  A61K31/337 ,  A61K45/06

CPC分类号： C07C311/21 ,  A61K31/18 ,  A61K31/337 ,  A61K45/06

摘要： Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

公开(公告)号：US20180208554A1

公开(公告)日：2018-07-26

申请号：US15743546

申请日：2016-07-08

申请人： University of Maryland, Baltimore

发明人： Steven Fletcher ,  Maryanna Lanning ,  Lijia Chen

IPC分类号： C07C311/21 ,  C07C229/64 ,  C07C311/51 ,  C07C311/29 ,  C07D215/58 ,  C07D257/02 ,  C07D261/12 ,  A61P35/02

CPC分类号： C07C311/21 ,  A61P35/02 ,  C07C229/64 ,  C07C311/29 ,  C07C311/51 ,  C07C2601/08 ,  C07D215/58 ,  C07D257/02 ,  C07D261/12 ,  C07D309/04

摘要： Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.

公开(公告)号：US09951022B2

公开(公告)日：2018-04-24

申请号：US15434678

申请日：2017-02-16

申请人： TACURION

发明人： Souichirou Kawazoe ,  Takahiro Akiba ,  Kiichi Sato ,  Akio Miyafuji ,  Kazuyoshi Obitsu ,  Junji Itoh ,  Shun Hirasawa ,  Hiroyuki Koshio

IPC分类号： A61K31/55 ,  C07D223/16

CPC分类号： C07D223/16 ,  C07C51/09 ,  C07C51/367 ,  C07C67/31 ,  C07C303/40 ,  C07C311/21 ,  C07D301/00

摘要： The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.

公开(公告)号：US20180093960A1

公开(公告)日：2018-04-05

申请号：US15285296

申请日：2016-10-04

申请人： California State University, Fresno ,  Mayo Foundation for Medical Education and Research

发明人： Santanu Maitra ,  Jungsu Kim

IPC分类号： C07D295/26 ,  C07C233/65 ,  C07D295/195 ,  C07C311/16 ,  C07D295/03 ,  C07C211/30 ,  A61K31/166 ,  A61K31/5375 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/18 ,  A61K31/137 ,  A61K31/167 ,  C07C233/75 ,  C07C233/64 ,  C07C311/21 ,  C07C311/20

CPC分类号： C07D295/26 ,  A61K31/137 ,  A61K31/166 ,  A61K31/167 ,  A61K31/18 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/5375 ,  C07C211/30 ,  C07C233/64 ,  C07C233/65 ,  C07C233/75 ,  C07C311/16 ,  C07C311/20 ,  C07C311/21 ,  C07C2601/14 ,  C07D295/03 ,  C07D295/195

摘要： This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.

公开(公告)号：US20170342025A1

公开(公告)日：2017-11-30

申请号：US15541113

申请日：2015-12-29

申请人： Swansea University ,  The University of Bath

发明人： Barry Victor Lloyd POTTER ,  Wolfgang DOHLE ,  Xiangdong SU ,  John NORMANTON ,  Edward DUDLEY ,  Yamni NIGAM

IPC分类号： C07C279/00 ,  C07D217/06 ,  C07C311/21 ,  C07C279/22 ,  A61K45/06 ,  A61K31/155 ,  A61K31/495 ,  A61K31/472 ,  A61K31/255 ,  A61K31/166 ,  C07D295/215 ,  C07C279/08

CPC分类号： C07C279/00 ,  A61K31/155 ,  A61K31/166 ,  A61K31/255 ,  A61K31/472 ,  A61K31/495 ,  A61K45/06 ,  C07C279/04 ,  C07C279/08 ,  C07C279/18 ,  C07C279/22 ,  C07C281/18 ,  C07C311/21 ,  C07D207/335 ,  C07D217/06 ,  C07D233/64 ,  C07D295/215 ,  Y02A50/401 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481

摘要： The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of bacteria, and are useful in the treatment or prophylaxis of a bacterial infection in an animal.