公开(公告)号：US20240052000A1

公开(公告)日：2024-02-15

申请号：US18257840

申请日：2021-12-15

Applicant: Novozymes A/S ,  University of Copenhagen

Inventor： Thomas Krogh Kallehauge ,  Annaleigh Ohrt Fehler ,  Adrian Sven Geissler ,  Jan Gorodkin ,  Jeppe Vinther

IPC: C07K14/32 ,  C12N15/75 ,  C12N9/26 ,  C12N9/24 ,  C12N9/50 ,  C12N9/88

CPC classification number: C07K14/32 ,  C12N15/75 ,  C12N9/2411 ,  C12N9/248 ,  C12N9/50 ,  C12N9/88 ,  C12Y304/21062 ,  C12Y402/02012

Abstract: The present invention relates to mutated bacterial host cells, said host cells producing a polypeptide of interest and having at least one disrupted flagellum gene, and to nucleic acid constructs and vectors encoding at least one flagellum polypeptide with reduced or eliminated activity as well as to methods of producing one or more polypeptide of interest in said host cells.