公开(公告)号：US20230117083A1

公开(公告)日：2023-04-20

申请号：US17794320

申请日：2021-01-22

申请人： Nuclera Nucleics Ltd.

发明人： Tobias William Barr Ost ,  Gordon Ross McInroy ,  Zachary Beyer Gaber ,  Harold Swerdlow ,  Cecilia Tognoloni

IPC分类号： C12P19/34 ,  C12N9/24

摘要： The invention relates to improved methods of enzymatic solid-supported nucleic acid synthesis that make use of terminal deoxynucleotidyl transferase (TdT) enzymes or modified terminal deoxynucleotidyl transferase (TdT) enzymes on polyacrylamide type supports. The invention further relates to the use of kits comprising said enzymes in a method of solid-supported nucleic acid synthesis.