公开(公告)号：US11542278B1

公开(公告)日：2023-01-03

申请号：US17514877

申请日：2021-10-29

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： A61K31/4427 ,  C07D471/22 ,  C07D498/22 ,  A61P35/00 ,  C07D513/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds of Formula (I): pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

公开(公告)号：US11667649B2

公开(公告)日：2023-06-06

申请号：US17524169

申请日：2021-11-11

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20220098212A1

公开(公告)日：2022-03-31

申请号：US17524169

申请日：2021-11-11

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D491/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US12037346B2

公开(公告)日：2024-07-16

申请号：US17718381

申请日：2022-04-12

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： A61K31/4353 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as a compound of Formula (I):




pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20220363696A1

公开(公告)日：2022-11-17

申请号：US17718381

申请日：2022-04-12

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as 4-amino-quinazolines, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20240352037A1

公开(公告)日：2024-10-24

申请号：US18745209

申请日：2024-06-17

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

CPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

公开(公告)号：US20240327435A1

公开(公告)日：2024-10-03

申请号：US18665844

申请日：2024-05-16

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： C07D519/00 ,  C07D487/04

CPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as 4-amino-quinazolines, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US12054498B2

公开(公告)日：2024-08-06

申请号：US17834135

申请日：2022-06-07

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： A61K31/4427 ,  A61P35/00 ,  C07D471/22 ,  C07D498/22 ,  C07D513/22

CPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds of Formula (I):




pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

公开(公告)号：US20230076627A1

公开(公告)日：2023-03-09

申请号：US17834127

申请日：2022-06-07

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D491/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20220340586A9

公开(公告)日：2022-10-27

申请号：US17524169

申请日：2021-11-11

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D491/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.