公开(公告)号：US12037346B2

公开(公告)日：2024-07-16

申请号：US17718381

申请日：2022-04-12

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： A61K31/4353 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as a compound of Formula (I):




pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20220363696A1

公开(公告)日：2022-11-17

申请号：US17718381

申请日：2022-04-12

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as 4-amino-quinazolines, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20240327435A1

公开(公告)日：2024-10-03

申请号：US18665844

申请日：2024-05-16

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： C07D519/00 ,  C07D487/04

CPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as 4-amino-quinazolines, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.