公开(公告)号：US12006314B2

公开(公告)日：2024-06-11

申请号：US17735011

申请日：2022-05-02

Applicant: Nuvation Bio Inc.

Inventor： David Hung ,  Jayakanth Kankanala ,  Christopher Paul Miller ,  Jeremy David Pettigrew ,  Son Minh Pham ,  Ihab S. Darwish

IPC: C07D471/04 ,  C07D403/10 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D471/04 ,  C07D403/10 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, such as a compound of Formula I:




or a tautomer, stereoisomer, mixture of stereoisomers, hydrate, solvate, isotopically enriched analog, or pharmaceutically acceptable salt thereof, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US20210214316A1

公开(公告)日：2021-07-15

申请号：US17096743

申请日：2020-11-12

Applicant: Nuvation Bio Inc.

Inventor： Son Minh Pham ,  Jayakanth Kankanala ,  Jeremy Pettigrew ,  Christopher Paul Miller

IPC: C07D237/32

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US11952349B2

公开(公告)日：2024-04-09

申请号：US17096743

申请日：2020-11-12

Applicant: Nuvation Bio Inc.

Inventor： Son Minh Pham ,  Jayakanth Kankanala ,  Jeremy Pettigrew ,  Christopher Paul Miller

IPC: C07D237/32

CPC classification number: C07D237/32

Abstract: The disclosure relates to anti-cancer compounds derived from a payload which binds to poly(ADP-ribose) polymerase (PARP) and a nuclear steroid-targeting epitope (B of Formula I), which components are covalently linked via a linker, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US20220340587A1

公开(公告)日：2022-10-27

申请号：US17701425

申请日：2022-03-22

Applicant: Nuvation Bio Inc.

Inventor： David Hung ,  Jayakanth Kankanala ,  Christopher Paul Miller ,  Jeremy David Pettigrew ,  Son Minh Pham ,  Ihab S. Darwish

IPC: C07D491/22 ,  C07D471/14

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US11834458B2

公开(公告)日：2023-12-05

申请号：US17701425

申请日：2022-03-22

Applicant: Nuvation Bio Inc.

Inventor： David Hung ,  Jayakanth Kankanala ,  Christopher Paul Miller ,  Jeremy David Pettigrew ,  Son Minh Pham ,  Ihab S. Darwish

IPC: C07D491/22 ,  A61K31/4745 ,  C07D471/14

CPC classification number: C07D491/22 ,  C07D471/14

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US20220380364A1

公开(公告)日：2022-12-01

申请号：US17735011

申请日：2022-05-02

Applicant: Nuvation Bio Inc.

Inventor： David Hung ,  Jayakanth Kankanala ,  Christopher Paul Miller ,  Jeremy David Pettigrew ,  Son Minh Pham

IPC: C07D471/04 ,  C07D403/10 ,  C07D413/14 ,  C07D417/14 ,  C07D403/14

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.