公开(公告)号：US20210061757A1

公开(公告)日：2021-03-04

申请号：US17046096

申请日：2019-04-11

Applicant: OLON S.p.A.

Inventor： Filippo NISIC ,  Faris GARIS ,  Corrado COLLI ,  Giorgio BERTOLINI ,  Mara SADA ,  Stefania BERTUOLO ,  Silvano RONZONI ,  Romano DI FABIO ,  Stefano MAIORANA

IPC: C07C269/06 ,  C07C213/02

Abstract: Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invention are said novel synthesis intermediates and their use for the preparation of active pharmaceutical ingredients.

公开(公告)号：US20180258028A1

公开(公告)日：2018-09-13

申请号：US15759859

申请日：2016-09-28

Applicant: OLON S.P.A.

Inventor： Corrado COLLI ,  Alessandro AGOSTI ,  Stefano MAIORANA ,  Federica COLOMBO ,  Giorgio BERTOLINI

IPC: C07C209/68 ,  C07C211/42 ,  C07D215/26

CPC classification number: C07C209/68 ,  C07C211/42 ,  C07C2602/08 ,  C07D215/26

Abstract: Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.