公开(公告)号：US20170037483A1

公开(公告)日：2017-02-09

申请号：US15298723

申请日：2016-10-20

Applicant: OLYMPUS CORPORATION

Inventor： Taro HAYASHI ,  Isao SAKANE ,  Yoko OHASHI

IPC: C12Q1/68 ,  G01N21/64 ,  G06K9/00 ,  G06T7/00 ,  G06T7/20 ,  G01N33/483 ,  C12N5/077

CPC classification number: C12Q1/6897 ,  C12N5/0657 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00 ,  G01N21/6486 ,  G01N33/4833 ,  G06K9/00134 ,  G06T7/0012 ,  G06T7/20 ,  G06T7/97 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30048

Abstract: A method for monitoring differentiation into cardiac muscle cells includes keeping, in an alive state, cells into which a reporter gene of luminescent protein configured to vary in luminescence intensity according to an expression of myocardial differentiation marker gene is introduced. The method includes acquiring a luminescence image as a still image by imaging light emitted from the cells in a light shielding state. The method includes acquiring sequential images with illuminating the cells. The method includes associating biological information obtained from the sequential images with biological information obtained from the still image.

Abstract translation: 用于监测心肌细胞分化的方法包括在活体状态下保持根据心肌分化标记基因的表达配置成发光强度变化的发光蛋白质的报道基因的细胞。 该方法包括通过在遮光状态下成像从单元发射的光来获取作为静止图像的发光图像。 该方法包括通过照亮单元获取顺序图像。 该方法包括将从顺序图像获得的生物信息与从静止图像获得的生物信息相关联。

公开(公告)号：US20210019580A1

公开(公告)日：2021-01-21

申请号：US16930793

申请日：2020-07-16

Applicant: OLYMPUS CORPORATION

Inventor： Isao SAKANE

IPC: G06K9/66

Abstract: An evaluation assistance method includes: acquiring a first image to be used for performance evaluation of trained models; generating a plurality of second images, each of the plurality of second images being a result of processing the first image by each of a plurality of trained models; and displaying each of the plurality of trained models in association with a corresponding second image of the plurality of second images.

公开(公告)号：US20210142474A1

公开(公告)日：2021-05-13

申请号：US17101170

申请日：2020-11-23

Applicant: OLYMPUS CORPORATION

Inventor： Takayuki NAKATOMI ,  Isao SAKANE

IPC: G06T7/00 ,  G01N33/50

Abstract: An image processing device includes a cell analyzer that analyzes an image of cells cultured within a culture container and that acquires the number of cell divisions experienced by each cell in the image, and also includes a statistical analyzer that calculates a statistical value indicating differentiation potency of each cell in the image from the number of cell divisions acquired by the cell analyzer. The statistical analyzer creates a frequency distribution of the number of cell divisions, and the statistical value represents a bias in the frequency distribution.

公开(公告)号：US20190095692A1

公开(公告)日：2019-03-28

申请号：US16048792

申请日：2018-07-30

Applicant: OLYMPUS CORPORATION

Inventor： Takayuki NAKATOMI ,  Satoshi ISHII ,  Isao SAKANE ,  Masakazu FUJII ,  Akira MATSUSHITA ,  Takashi MIYOSHI

IPC: G06K9/00 ,  G06K9/46

CPC classification number: G06K9/00147 ,  G06K9/469

Abstract: Provided is an image-processing device that includes: a prosessor including hardware, the prosessor configured to: analyze an image of the inside of a culture vessel that cultures cells, and acquire quantitative data of living cells and quantitative data of dead cells inside the culture vessel; and generate comparison data that allows comparison of the acquired quantitative data of the living cells and the acquired quantitative data of the dead cells.

公开(公告)号：US20220130043A1

公开(公告)日：2022-04-28

申请号：US17568925

申请日：2022-01-05

Applicant: OLYMPUS CORPORATION

Inventor： Akira MATSUSHITA ,  Isao SAKANE ,  Yu HIROSAWA ,  Takuma DEZAWA

IPC: G06T7/00 ,  C12M1/00 ,  C12M3/00 ,  C12M1/12

Abstract: A method for evaluating an adherent cell includes: obtaining an image of an adherent cell accommodated within a culture container; and determining whether the adherent cell is adhering to the culture container based on at least a profile shape of a contact portion of the adherent cell that is in contact with the culture container, the profile shape being specified from the image.

公开(公告)号：US20210158588A1

公开(公告)日：2021-05-27

申请号：US17164123

申请日：2021-02-01

Applicant: OLYMPUS CORPORATION

Inventor： Takashi MIYOSHI ,  Isao SAKANE ,  Taiji MINE ,  Takayuki NAKATOMI

IPC: G06T11/60 ,  G06K9/00 ,  G06T7/11 ,  G06T7/62

Abstract: Provided is a data-creation assistance apparatus which is an apparatus that assists data creation work in which an annotation is added to each cell in an image containing cells, the data-creation assistance apparatus including: a processor including hardware, the processor being configured to: acquire image data including the image; extract information related to the cells from the acquired image data; set a size of divided regions on the basis of the extracted information related to the cells; and divide the image into the divided regions; and a display that displays each of the divided regions which have been divided.