专利检索 ap:("ONCOIMMUNE, INC." OR "CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER") AND inv:"Mingyue LIU" 第 1 页

1.

发明申请
CD80 and CD86 Binding Protein Compositions and Uses Thereof 审中-公开

公开(公告)号：US20190263889A1

公开(公告)日：2019-08-29

申请号：US16333888

申请日：2017-09-19

申请人： ONCOIMMUNE, INC. , CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Yang LIU , Pan ZHENG , Martin DEVENPORT , Wei WU , Xuexiang DU , Mingyue LIU , Fei TANG

IPC分类号： C07K14/705 , C07K16/28 , A61P35/00 , A61P37/06

摘要： This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.