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公开(公告)号:US20190389837A1
公开(公告)日:2019-12-26
申请号:US16480514
申请日:2018-01-25
IPC分类号: C07D401/14
摘要: The present invention relates to an ethane-sulfonate salt of N-{5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide, which has an Axl-inhibiting activity and is useful as a prophylactic and/or therapeutic agent for immune diseases, cancer and the like, a crystal thereof, and a pharmaceutical composition thereof.
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公开(公告)号:US20210395250A1
公开(公告)日:2021-12-23
申请号:US17297649
申请日:2019-11-29
发明人: Takayuki FUJITO , Shizuka ONO , Shuhei OHTANI
IPC分类号: C07D471/04
摘要: A novel crystal form of (3S)-3-[2-(6-amino-2-fluoropyridin-3-yl)-4-fluoro-1H-imidazol-5-yl]-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2,3-dihydroindolizin-5(1H)-one, which is (3S)-3-[2-(6-amino-2-fluoropyridin-3-yl)-4-fluoro-1H-imidazol-5-yl]-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2,3-dihydroindolizin-5(1H)-one-3-hydroxybenzoic acid (1/1).
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公开(公告)号:US20170240527A1
公开(公告)日:2017-08-24
申请号:US15504514
申请日:2015-08-17
发明人: Jun TAKEUCHI , Satoshi ITADANI , Masahiro IKURA , Masato HIGASHINO , Hideomi KIJIMA , Shizuka ONO , Tetsuya YASUHIRO , Takeshi NAGAURA
IPC分类号: C07D401/12 , A61K45/06 , C07C309/04 , A61K31/506 , C07C309/30 , C07C309/29
CPC分类号: C07D401/12 , A61K31/506 , A61K45/00 , A61K45/06 , C07B2200/13 , C07C309/04 , C07C309/29 , C07C309/30 , C07D401/14
摘要: In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and in addition thereto, is excellent in solubility and absorbability against free bases. The compound of the present invention has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and is excellent in solubility and absorbability against free bases, and is therefore useful as a prophylactic and/or therapeutic agent for Trk-related diseases.
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