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公开(公告)号：US20140039004A1
公开(公告)日：2014-02-06
申请号：US13952131
申请日：2013-07-26
发明人： Hiroki OKADA , Takashi KONEMURA
IPC分类号： A61K31/426 , A61K45/06
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/444 , A61K45/06 , A61K2300/00
摘要： The development of agents for gastroesophageal reflux disease, in which existing treatment is not effective, is strongly demanded. An object of the present invention is to provide an agent for preventing or relapse-preventing, treating or ameliorating such gastroesophageal reflux disease. 4-[({6-[Isobutyl(1,3-thiazol-2-ylsulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}oxy)methyl]-3-methyl benzoic acid, a salt thereof or a prodrug thereof is effective in the prevention or relapse prevention, treatment or amelioration of gastroesophageal reflux disease.
摘要翻译： 需要发展现有治疗无效的胃食管反流病药物。 本发明的目的是提供一种用于预防或复发预防，治疗或改善这种胃食管反流病的药剂。 4 - [（{6- [异丁基（1,3-噻唑-2-基磺酰基）氨基] -2,3-二氢-1H-茚-5-基}氧基）甲基] -3-甲基苯甲酸盐 或其前药在预防或复发预防，治疗或改善胃食管反流病方面是有效的。
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公开(公告)号：US20210332009A1
公开(公告)日：2021-10-28
申请号：US17264603
申请日：2019-07-30
发明人： Shoji NOJIMA , Kenji SASAKI , Tohru KAMBE , Takashi KONEMURA , Yoshikazu GOTO
IPC分类号： C07C311/21
摘要： A compound represented by general formula (I) (in the formula, all symbols are as described in the description) or a salt thereof has a potent nerve-protecting and/or -repairing activity, and therefore can be used as a therapeutic agent for neuropathy (e.g., chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, periarteritis nodosa, allergic vasculitis, diabetic peripheral neuropathy, entrapment neuropathy, peripheral neuropathy associated with the administration of a chemotherapeutic drug, or peripheral neuropathy associated with Charcot-Marie-Tooth disease).
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公开(公告)号：US20220089532A1
公开(公告)日：2022-03-24
申请号：US17544616
申请日：2021-12-07
发明人： Shoji NOJIMA , Kenji SASAKI , Tohru KAMBE , Takashi KONEMURA , Yoshikazu GOTO
IPC分类号： C07C311/21
摘要： A compound represented by general formula (I) (in the formula, all symbols are as described in the description) or a salt thereof has a potent nerve-protecting and/or -repairing activity, and therefore can be used as a therapeutic agent for neuropathy (e.g., chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, periarteritis nodosa, allergic vasculitis, diabetic peripheral neuropathy, entrapment neuropathy, peripheral neuropathy associated with the administration of a chemotherapeutic drug, or peripheral neuropathy associated with Charcot-Marie-Tooth disease).
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