公开(公告)号：US20170327439A1

公开(公告)日：2017-11-16

申请号：US15532389

申请日：2014-12-03

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Kensuke KUSUMI ,  Haruto KURATA ,  Atsushi NAGANAWA ,  Yasuyo KODERA ,  Yuichi INAGAKI ,  Hiroya TAKIZAWA ,  Mark Allan WOLF ,  Joseph RAKER

IPC分类号： C07C13/48 ,  C07D205/04 ,  A61K31/397 ,  A61K31/19 ,  A61K31/015 ,  C07D401/10 ,  C07C13/20 ,  C07C2602/10

CPC分类号： C07C13/48 ,  A61K31/015 ,  A61K31/19 ,  A61K31/397 ,  C07C13/20 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/16 ,  C07D401/10 ,  C07D403/10

摘要： A compound represented by general formula (I) (wherein, all the symbols are as defined in the specification) has a selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skeleton; .i.e., due to having a short linker of one atom or less as L in general formula (I), and can therefore serve as an agent for treating S1P5-mediated disease, e.g., neurodegenerative disease such as schizophrenia.