公开(公告)号：US10369149B2

公开(公告)日：2019-08-06

申请号：US15567224

申请日：2015-12-30

申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

发明人： Jong Yeon Hwang ,  Hyoung Rae Kim ,  Jae Du Ha ,  Sung Yun Cho ,  Hee Jung Jung ,  Pilho Kim ,  Chang Soo Yun ,  Chong Ock Lee ,  Chi Hoon Park ,  Chong Hak Chae ,  Sunjoo Ahn

IPC分类号： A61K31/506 ,  C07D239/30 ,  C07D239/48 ,  A23L33/10 ,  A61P35/00 ,  C07B43/04 ,  C07C13/48

摘要： The present invention relates to a 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.

公开(公告)号：US09887372B2

公开(公告)日：2018-02-06

申请号：US15167779

申请日：2016-05-27

申请人： SAMSUNG DISPLAY CO., LTD.

发明人： Mieun Jun ,  Soobyung Ko ,  Haejin Kim ,  Youngkook Kim ,  Seokhwan Hwang

IPC分类号： C07C13/48 ,  C07D401/00 ,  C07F7/00 ,  C07F7/08 ,  H01L51/00 ,  H01L27/32 ,  C09K11/06 ,  H01L51/50

CPC分类号： H01L51/0094 ,  C07F7/0816 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1088 ,  C09K2211/1096 ,  H01L27/3211 ,  H01L51/0058 ,  H01L51/0059 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0073 ,  H01L51/5012 ,  H01L51/5056

摘要： According to one or more embodiments, an organic light-emitting device may include: a first electrode; a second electrode facing the first electrode, and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer, wherein the organic layer includes an amine-based compound represented by Formula 1:

公开(公告)号：US20170327439A1

公开(公告)日：2017-11-16

申请号：US15532389

申请日：2014-12-03

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Kensuke KUSUMI ,  Haruto KURATA ,  Atsushi NAGANAWA ,  Yasuyo KODERA ,  Yuichi INAGAKI ,  Hiroya TAKIZAWA ,  Mark Allan WOLF ,  Joseph RAKER

IPC分类号： C07C13/48 ,  C07D205/04 ,  A61K31/397 ,  A61K31/19 ,  A61K31/015 ,  C07D401/10 ,  C07C13/20 ,  C07C2602/10

CPC分类号： C07C13/48 ,  A61K31/015 ,  A61K31/19 ,  A61K31/397 ,  C07C13/20 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/16 ,  C07D401/10 ,  C07D403/10

摘要： A compound represented by general formula (I) (wherein, all the symbols are as defined in the specification) has a selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skeleton; .i.e., due to having a short linker of one atom or less as L in general formula (I), and can therefore serve as an agent for treating S1P5-mediated disease, e.g., neurodegenerative disease such as schizophrenia.

公开(公告)号：US20100327270A1

公开(公告)日：2010-12-30

申请号：US12867648

申请日：2009-02-13

申请人： Arne Buesing ,  Holger Heil ,  Philipp Stoessel

发明人： Arne Buesing ,  Holger Heil ,  Philipp Stoessel

IPC分类号： H01L51/54 ,  C07C13/48 ,  C07D235/18 ,  C07D251/14 ,  C07D211/68 ,  C07D333/08 ,  C07D333/00 ,  C07D215/06 ,  C07D213/04 ,  C07C211/54

CPC分类号： H01L51/0058 ,  C07C13/567 ,  C07C13/72 ,  C07C15/20 ,  C07C15/30 ,  C07C15/38 ,  C07C211/54 ,  C07C211/61 ,  C07C2601/14 ,  C07C2603/18 ,  C07C2603/24 ,  C07C2603/26 ,  C07C2603/42 ,  C07C2603/52 ,  C07C2603/94 ,  C07D221/10 ,  C07D235/18 ,  C07D251/24 ,  C07D333/08 ,  C07D333/72 ,  C07D471/04 ,  C09K11/06 ,  C09K2211/1014 ,  C09K2211/1044 ,  C09K2211/1059 ,  H01L51/006 ,  H01L51/0081 ,  H01L51/5048 ,  H05B33/14 ,  Y02E10/549 ,  Y10S428/917

摘要： The present invention relates to the compounds of the formula (1) and to organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as host material in the emitting layer and/or as electron-transport material.

摘要翻译： 本发明涉及式（1）的化合物和有机电致发光器件，特别是蓝色发光器件，其中这些化合物用作发光层和/或电子传输材料中的主体材料。

公开(公告)号：US07829597B2

公开(公告)日：2010-11-09

申请号：US10573232

申请日：2004-09-29

申请人： Philippe G. Nantermet ,  Hemaka Anthony Rajapakse ,  Harold G. Selnick

发明人： Philippe G. Nantermet ,  Hemaka Anthony Rajapakse ,  Harold G. Selnick

IPC分类号： C07C15/12 ,  C07C13/48 ,  A61K31/135

CPC分类号： C07D213/81 ,  C07C255/57 ,  C07C311/08 ,  C07C2601/02 ,  C07D207/06 ,  C07D207/08 ,  C07D213/76 ,  C07D295/192 ,  C07D333/20 ,  C07D405/04

摘要： The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及作为β-分泌酶的抑制剂的式（I）化合物，其可用于治疗涉及β-分泌酶的疾病，例如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US20080185555A1

公开(公告)日：2008-08-07

申请号：US11986017

申请日：2007-11-19

申请人： Antonio Facchetti ,  Tobin J. Marks ,  Zhiming M. Wang

发明人： Antonio Facchetti ,  Tobin J. Marks ,  Zhiming M. Wang

IPC分类号： C07D241/46 ,  C07D209/56 ,  C07F9/02 ,  C07C49/105 ,  C09K3/00 ,  C07C13/48 ,  C07D219/00 ,  C07D221/06

CPC分类号： H01L51/0053 ,  C09B5/62 ,  H01L51/0545 ,  H01L51/424 ,  H01L51/5012 ,  Y02E10/549 ,  Y02P70/521

摘要： Acene-based compounds that can be used to prepare n-type semiconductor materials are provided with processes for preparing the same. Composites and electronic devices including n-type semiconductor materials prepared from these compounds also are provided.

摘要翻译： 可用于制备n型半导体材料的基于乙烯的化合物具有制备它们的方法。 还提供了包括由这些化合物制备的n型半导体材料的复合材料和电子器件。

公开(公告)号：US5886242A

公开(公告)日：1999-03-23

申请号：US6003

申请日：1998-01-12

申请人： Karl-Heinz Etzbach ,  Paul Delavier ,  Karl Siemensmeyer ,  Gerhard Wagenblast ,  Lothar Laupichler ,  Volkmar Vill

发明人： Karl-Heinz Etzbach ,  Paul Delavier ,  Karl Siemensmeyer ,  Gerhard Wagenblast ,  Lothar Laupichler ,  Volkmar Vill

IPC分类号： G02F1/13 ,  C07C67/08 ,  C07C67/31 ,  C07C69/54 ,  C07C69/757 ,  C07C69/76 ,  C07C69/773 ,  C07C69/92 ,  C07C69/94 ,  C07D239/34 ,  C07D285/12 ,  C07D309/30 ,  C07D493/04 ,  C07D521/00 ,  C07H15/18 ,  C08F20/30 ,  C09K19/04 ,  C09K19/20 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/38 ,  C07C13/465 ,  C07C13/48 ,  C07C15/12 ,  C07D239/26

CPC分类号： C07C69/92 ,  C07C69/94 ,  C08F20/30 ,  C09K19/0422 ,  C09K19/2028 ,  C09K19/30 ,  C09K19/3068 ,  C09K19/322 ,  C09K19/3463 ,  C09K19/3469 ,  C09K19/3491 ,  C09K2019/0448 ,  C09K2019/323 ,  C09K2019/3408 ,  C09K2019/3425 ,  C09K2019/3427

摘要： The invention relates to chiral compounds containing at least one divalent or polyvalent chiral group, at least one polymerizable group, at least one spacer and at least one mesogenic group, and to their use as polymerizable, chiral dopes for the preparation of cholesteric networks.The novel compounds are suitable for use in electro-optical displays or as chiral dopes for nematic or cholesteric liquid crystals in order to produce layers which reflect in colors.

摘要翻译： 本发明涉及含有至少一个二价或多价手性基团，至少一个可聚合基团，至少一个间隔基和至少一个介晶基团的手性化合物，以及它们作为用于制备胆甾型网络的可聚合的手性掺杂物的用途。 新型化合物适用于电光显示器或用作向列型或胆甾型液晶的手性掺杂物，以便产生以颜色反射的层。

公开(公告)号：US5789634A

公开(公告)日：1998-08-04

申请号：US795019

申请日：1997-02-05

申请人： Jeffrey M. Sullivan ,  Hamlin H. Barnes

发明人： Jeffrey M. Sullivan ,  Hamlin H. Barnes

IPC分类号： C07C1/32 ,  C07C13/465 ,  C07C13/48 ,  C07C17/35 ,  C07C25/22 ,  C07F7/08 ,  C07F17/00 ,  C07C22/00

CPC分类号： C07F17/00 ,  C07C1/326 ,  C07C17/35 ,  C07C25/22 ,  C07C2102/08

摘要： Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.

摘要翻译： 描述了新的2-取代的7-卤代茚和用于合成这种茚的方法。 2-取代的7-卤代茚可以与任何芳基偶联以产生茂金属催化剂中间体。

公开(公告)号：US5455265A

公开(公告)日：1995-10-03

申请号：US16404

申请日：1993-02-11

申请人： Roshantha A. S. Chandraratna

发明人： Roshantha A. S. Chandraratna

IPC分类号： C07D333/38 ,  A61K31/19 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K45/00 ,  A61P3/00 ,  A61P9/10 ,  A61P17/00 ,  A61P37/06 ,  C07C13/48 ,  C07C33/38 ,  C07C33/50 ,  C07C35/21 ,  C07C35/52 ,  C07C47/238 ,  C07C47/24 ,  C07C47/277 ,  C07C49/225 ,  C07C49/237 ,  C07C49/255 ,  C07C61/39 ,  C07C69/618 ,  C07C69/753 ,  C07C69/76 ,  C07C233/02 ,  C07C233/58 ,  C07D307/68 ,  C07F9/54

CPC分类号： A61K31/19 ,  A61K31/34 ,  A61K31/38

摘要： Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid receptor sites in preference to the RAR retinoid receptor sites. A compound is defined to be a selective agonist of the RXR receptor site if the compound is at least approximately ten times more effective as an agonist in the RXR receptor sites than in the RAR receptor sites.

公开(公告)号：US5354899A

公开(公告)日：1994-10-11

申请号：US72242

申请日：1993-06-04

申请人： Toshio Sato ,  Ikuo Ito ,  Kyoichi Takeda

发明人： Toshio Sato ,  Ikuo Ito ,  Kyoichi Takeda

IPC分类号： C07C2/72 ,  C07C5/31 ,  C07C5/367 ,  C07C13/48 ,  C07C15/24 ,  C07C15/44 ,  C07C51/21 ,  C07C51/265 ,  C07C63/40 ,  C07C63/48

CPC分类号： C07C5/367 ,  C07C2/72 ,  C07C51/265 ,  C07C2523/04 ,  C07C2531/02 ,  C07C2531/26

摘要： There is disclosed a mass production process of 1,4,5,8-naphthalene tetracarboxylic acid with high collection efficiency. In the presence of an alkaline metallic catalyst, 1,3-butadiene was added to the ethyl radicals of ethyl-p-xylene, and cyclized to 1,4,5,8-tetramethyl-1,2,3,4-tetrahydronaphthalene which was further dehydrogenated and oxidized to obtain 1,4,5,8-naphthalene tetracarboxylic acid, so that a constant supply of inexpensive 1,4,5,8-naphthalene tetracarboxylic acid can be achieved as an intermediate raw material for dye, pigment, resins, or the like.

摘要翻译： 公开了具有高收集效率的1,4,5,8-萘四羧酸的批量生产方法。 在碱金属催化剂的存在下，将1,3-丁二烯加入到乙基对二甲苯的乙基中，并环化成1,4,5,8-四甲基-1,2,3,4-四氢化萘，其中 进一步脱氢氧化得到1,4,5,8-萘四羧酸，从而可以实现廉价的1,4,5,8-萘四羧酸的稳定供应，作为染料，颜料， 树脂等。