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公开(公告)号:US20190160152A1
公开(公告)日:2019-05-30
申请号:US16307631
申请日:2017-06-08
申请人: OPKO BIOLOGICS LTD.
发明人: Oren HERSHKOVITZ , Ahuva BAR-ILAN , Vered LEV , Yaron TZUR
摘要: Pharmaceutical formulations and pharmaceutical compositions comprising reverse PEGylated oxyntomodulin conjugates, and methods of producing, and using the same are described. Conjugates include those attaching a polyethylene glycol polymer (PEG polymer) and 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) to a oxyntomodulin peptide, wherein the PEG polymer is attached to the amino terminus or to an amino residue within the oxyntomodulin via a flexible linker, wherein the flexible linker comprises a Fmoc or a FMS.