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    LONG-ACTING OXYNTOMODULIN VARIANTS AND METHODS OF PRODUCING SAME
    1.
    发明申请
    LONG-ACTING OXYNTOMODULIN VARIANTS AND METHODS OF PRODUCING SAME 有权
    长效氧自由基变异体及其生产方法

    公开(公告)号：US20150072924A1

    公开(公告)日：2015-03-12

    申请号：US14395441

    申请日：2013-04-17

    申请人： OPKO Biologics Ltd.

    发明人： Udi Eyal Fima ,  Oren Hershkovitz

    IPC分类号： C07K14/575 ,  C07K14/59

    CPC分类号： C07K14/575 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/24 ,  A61K38/26 ,  C07K14/59 ,  C07K14/605 ,  C07K2319/75

    摘要： This invention is directed to a chorionic gonadotrophin carboxy terminal peptide (CTP) modified dual GLP-1/Glucagon receptor agonist, and methods of producing and using the same. In one embodiment, the present invention provides a CTP-modified polypeptide comprising a dual GLP-1/Glucagon receptor agonist and at least one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus or carboxy terminus of said agonist.

    摘要翻译： 本发明涉及绒毛膜促性腺激素羧基末端肽（CTP）修饰的双重GLP-1 /胰高血糖素受体激动剂及其制备和使用方法。 在一个实施方案中，本发明提供了包含双GLP-1 /胰高血糖素受体激动剂和连接于所述激动剂的氨基末端或羧基末端的至少一个绒毛膜促性腺激素羧基末端肽（CTP）的CTP-修饰的多肽。

    Pegylated OXM variants
    2.
    发明授权
    Pegylated OXM variants 有权

    公开(公告)号：US10537646B2

    公开(公告)日：2020-01-21

    申请号：US14405597

    申请日：2013-06-04

    申请人： OPKO Biologics Ltd.

    发明人： Udi Eyal Fima ,  Oren Hershkovitz

    IPC分类号： A61K38/26 ,  C07K14/605 ,  C07K1/00 ,  A61K47/60 ,  A61K38/22

    摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

    Long-acting oxyntomodulin variants and methods of producing same
    3.
    发明授权
    Long-acting oxyntomodulin variants and methods of producing same 有权
    长效胃泌酸调节蛋白变体及其制备方法

    公开(公告)号：US09522945B2

    公开(公告)日：2016-12-20

    申请号：US14395441

    申请日：2013-04-17

    申请人： OPKO Biologics Ltd.

    发明人： Udi Eyal Eyal Fima ,  Oren Hershkovitz

    IPC分类号： A61K38/24 ,  C07K14/575 ,  A61K38/26 ,  A61K9/00 ,  C07K14/59 ,  A61K38/00

    CPC分类号： C07K14/575 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/24 ,  A61K38/26 ,  C07K14/59 ,  C07K14/605 ,  C07K2319/75

    摘要： This invention is directed to a chorionic gonadotrophin carboxy terminal peptide (CTP) modified dual GLP-1/glucagon receptor agonist, and methods of producing and using the same. In one embodiment, the present invention provides a CTP-modified polypeptide comprising a dual GLP-1/glucagon receptor agonist and at least one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus or carboxy terminus of the agonist.

    摘要翻译： 本发明涉及绒毛膜促性腺激素羧基末端肽（CTP）修饰的双重GLP-1 /胰高血糖素受体激动剂及其制备和使用方法。 在一个实施方案中，本发明提供了包含双GLP-1 /胰高血糖素受体激动剂和连接于激动剂的氨基末端或羧基末端的至少一个绒毛膜促性腺激素羧基末端肽（CTP）的CTP-修饰的多肽。

    LONG-ACTING GLP-2 ANALOGS
    4.
    发明申请
    LONG-ACTING GLP-2 ANALOGS 审中-公开

    公开(公告)号：US20200254065A1

    公开(公告)日：2020-08-13

    申请号：US16787810

    申请日：2020-02-11

    申请人： OPKO Biologics Ltd.

    发明人： Oren Hershkovitz ,  Ahuva Bar-Ilan ,  Vered Lev

    IPC分类号： A61K38/26 ,  A61K47/65 ,  A61K47/60

    摘要： Compositions which include glucagon-like peptide-2 (GLP-2) analogs, GLP-2 analogs with reversible or non-reversible linkers attached to one or more amino acid positions of the GLP-2 analog, and GLP-2 analogs linked to one or more polyethylene glycol polymers (PEG) via reversible or non-reversible linkers are disclosed. Also disclosed are pharmaceutical compositions comprising: the GLP-2 analogs; GLP-2 analogs linked solely to reversible or non-reversible linkers; the reverse PEGylated GLP-2 analogs; and the non-reversibly PEGylated GLP-2 analogs, as well as methods of using the same.

    Pegylated OXM variants
    6.
    发明授权
    Pegylated OXM variants 有权

    公开(公告)号：US10166295B2

    公开(公告)日：2019-01-01

    申请号：US14725883

    申请日：2015-05-29

    申请人： Opko Biologics Ltd.

    发明人： Udi Eyal Fima ,  Oren Hershkovitz

    IPC分类号： A61K38/26 ,  A61K47/48 ,  A61K38/22

    摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

    PEGYLATED OXM VARIANTS
    10.
    发明申请
    PEGYLATED OXM VARIANTS 审中-公开
    聚乙二醇变体

    公开(公告)号：US20150148289A1

    公开(公告)日：2015-05-28

    申请号：US14405597

    申请日：2013-06-04

    申请人： OPKO Biologics Ltd.

    发明人： Udi Eyal Fima ,  Oren Hershkovitz

    IPC分类号： A61K47/48 ,  A61K38/26

    摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

    摘要翻译： 公开了包含通过可逆接头如9-芴基甲氧基羰基（Fmoc）或2-磺基-9-芴基甲氧基羰基（FMS）连接的胃泌酸调节蛋白和聚乙二醇聚合物（PEG聚合物）的组合物。 还公开了包含反向聚乙二醇化的胃泌酸调节素的药物组合物及其使用方法。