公开(公告)号：US20240299511A1

公开(公告)日：2024-09-12

申请号：US18273087

申请日：2022-01-26

Applicant: UNIVERSITY OF PRETORIA

Inventor： Robert Peter MILLAR

IPC: A61K39/00 ,  A61P15/16 ,  A61P15/18 ,  C07K14/005 ,  C07K14/475 ,  C07K14/59

CPC classification number: A61K39/0006 ,  A61P15/16 ,  A61P15/18 ,  C07K14/005 ,  C07K14/475 ,  C07K14/59 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K2319/40 ,  C12N2730/10122

Abstract: This invention relates to an immunogen comprising a gonadotropin releasing hormone (GnRH) peptide sequence, a kisspeptin peptide sequence and a stimulant of raising an immune response, such an immunogen for use in a method to regulate the release of hormones in a vertebrate including modulation of reproductive hormones, to reduce fertility in a vertebrate and to treat hormone-dependent diseases including hormone-dependent tumours including prostate tumours, breast, ovary and endometrial tumours, benign hyperplasia including benign prostatic hyperplasia and uterine fibroids, endometriosis, polycystic ovarian disease, infertility, sexual dysfunction and any disorder that would benefit from an increased or decreased GnRH-dependent activity and a vaccine formulation comprising the immunogen. The invention also relates to the use of the immunogen in the preparation of a medicament for use in a method to regulate the release of hormones in a vertebrate.

公开(公告)号：US20240228542A1

公开(公告)日：2024-07-11

申请号：US17914303

申请日：2021-03-26

Applicant: A28 Therapeutics Inc.

Inventor： Carola Leuschner ,  Hector Alila ,  Anil Sood ,  Mark Kim

IPC: C07K7/23 ,  A61K31/704 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07K7/08 ,  C07K14/59

CPC classification number: C07K7/23 ,  A61K31/704 ,  A61K47/64 ,  A61P35/00 ,  C07K7/08 ,  C07K14/59 ,  A61K38/00 ,  C07K2319/00

Abstract: The invention relates to fusion constructs and checkpoint inhibitors, methods of using fusion constructs and checkpoint inhibitors, and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.

公开(公告)号：US11952407B2

公开(公告)日：2024-04-09

申请号：US17246348

申请日：2021-04-30

Applicant: Ferring International Center SA

Inventor： Ian Cottingham ,  Daniel Plaksin ,  Richard Boyd White

IPC: C07K14/59 ,  A61K38/00

CPC classification number: C07K14/59 ,  A61K38/00

Abstract: Preparations including recombinant FSH (rFSH).

公开(公告)号：US11911443B2

公开(公告)日：2024-02-27

申请号：US17498262

申请日：2021-10-11

Applicant: THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD. ,  B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY

Inventor： Ari-Angel Porgador ,  David Ben-Menahem ,  Roee Atlas

IPC: A61K38/19 ,  A61K38/00 ,  A61K38/18 ,  A61K47/64 ,  C07K14/55 ,  C07K14/59 ,  C07K14/61 ,  C07K19/00

CPC classification number: A61K38/19 ,  A61K38/18 ,  A61K47/642 ,  C07K14/55 ,  C07K14/59 ,  C07K14/61 ,  C07K19/00 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/33

Abstract: Peptides derived from NKp44 protein, chimeric peptides, nucleotides encoding same and pharmaceutical compositions comprising same, are provided. Further, methods of extending the biological half-life of a protein of interest are provided.

公开(公告)号：US20230242608A1

公开(公告)日：2023-08-03

申请号：US17790385

申请日：2020-12-23

Applicant: Natalia CEAGLIO ,  UNIVERSIDAD NACIONAL DEL LITORAL ,  CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) ,  BIOTECNOFE S.A.

Inventor： Natalia Ceaglio ,  Claudio Prieto ,  Diego Fontana ,  Celeste Rodriguez ,  Belén Tardivo ,  Sebastián Antuna

IPC: C07K14/59 ,  C12N15/86 ,  A61P15/08 ,  A61K9/19

CPC classification number: C07K14/59 ,  C12N15/86 ,  A61P15/08 ,  A61K9/19 ,  C12N2740/16043 ,  A61K38/00

Abstract: The present invention describes a method for obtaining a mammalian cell line that expresses a recombinant equine chorionic gonadotropin (reCG) hormone. A cell line expressing reCG, a large-scale method for producing reCG, a reCG with a higher biological activity regarding PMSG, formulations containing reCG, nucleic acids encoding reCG and uses are also described.

公开(公告)号：US20190194246A1

公开(公告)日：2019-06-27

申请号：US16143917

申请日：2018-09-27

Applicant: CEM Corporation

Inventor： JONATHAN M. COLLINS

IPC: C07K1/04 ,  C07K1/06 ,  C07K1/14 ,  C07K7/08 ,  C07K7/16 ,  C07K14/005 ,  C07K14/46 ,  C07K14/47 ,  C07K14/575 ,  C07K14/59 ,  C07K14/605 ,  C07K14/635 ,  C07K14/645 ,  C07K14/705 ,  C07K14/815 ,  C07K1/107 ,  C12N7/00 ,  B01J19/12

CPC classification number: C07K1/045 ,  B01J19/126 ,  B01J2204/005 ,  B01J2219/00058 ,  B01J2219/0879 ,  B01J2219/1248 ,  C07K1/04 ,  C07K1/063 ,  C07K1/1075 ,  C07K1/14 ,  C07K7/08 ,  C07K7/16 ,  C07K14/005 ,  C07K14/463 ,  C07K14/4701 ,  C07K14/4723 ,  C07K14/575 ,  C07K14/57572 ,  C07K14/59 ,  C07K14/605 ,  C07K14/635 ,  C07K14/645 ,  C07K14/705 ,  C07K14/815 ,  C12N7/00 ,  C12N2740/16322

Abstract: An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

公开(公告)号：US20190127432A1

公开(公告)日：2019-05-02

申请号：US16116080

申请日：2018-08-29

Applicant: TROPHOGEN INC.

Inventor： Mariusz Szkudlinski ,  Bruce D. Weintraub

IPC: C07K14/59

CPC classification number: C07K14/59 ,  A61K38/00

Abstract: This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type counterparts. The analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity.

公开(公告)号：US10018618B2

公开(公告)日：2018-07-10

申请号：US15138048

申请日：2016-04-25

Applicant: Peptide BioSciences, Inc.

Inventor： Elliot Altman

IPC: C12N15/00 ,  C12N15/62 ,  G01N33/50 ,  C07K7/06 ,  C07K7/08 ,  C07K7/14 ,  C07K14/195 ,  C07K14/245 ,  C07K14/425 ,  C07K14/585 ,  C07K14/59 ,  C07K14/605 ,  C07K14/61 ,  C07K14/62 ,  C07K14/645 ,  C12N15/10 ,  C12N15/63 ,  C12N15/67 ,  C12N15/72 ,  C40B40/02 ,  G01N33/68 ,  C07K14/435 ,  C07K14/46 ,  C07K14/575 ,  C07K14/58 ,  C07K14/63 ,  C07K14/655 ,  C07K14/665 ,  A61K38/00

CPC classification number: G01N33/5008 ,  C07K7/06 ,  C07K7/08 ,  C07K7/14 ,  C07K14/195 ,  C07K14/245 ,  C07K14/425 ,  C07K14/435 ,  C07K14/43536 ,  C07K14/43568 ,  C07K14/43572 ,  C07K14/463 ,  C07K14/575 ,  C07K14/58 ,  C07K14/585 ,  C07K14/59 ,  C07K14/605 ,  C07K14/61 ,  C07K14/62 ,  C07K14/63 ,  C07K14/645 ,  C07K14/655 ,  C07K14/665 ,  C07K2319/00 ,  C12N15/1037 ,  C12N15/62 ,  C12N15/635 ,  C12N15/67 ,  C12N15/72 ,  C40B40/02 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/68 ,  G01N33/6845

Abstract: An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.

公开(公告)号：US20180094279A1

公开(公告)日：2018-04-05

申请号：US15559272

申请日：2016-03-30

Applicant: Glycotope GmbH

Inventor： Steffen GOLETZ ,  Doreen JAHN ,  Antje DANIELCZYK

IPC: C12N15/85 ,  C12N15/66 ,  C07K14/47 ,  G01N33/50

CPC classification number: C12N15/85 ,  C07K14/473 ,  C07K14/59 ,  C07K14/7151 ,  C12N15/66 ,  G01N33/5047

Abstract: The present invention pertains to the field of recombinant protein production. Novel expression cassettes comprising elements of the human globin gene clusters are provided which show enhanced expression rates of proteins or polypeptides of interest.

公开(公告)号：US20180079794A1

公开(公告)日：2018-03-22

申请号：US15690061

申请日：2017-08-29

Applicant: Ferring International Center SA

Inventor： Ian Cottingham ,  Daniel Plaksin ,  Richard Boyd White

IPC: C07K14/59 ,  A61K38/00

CPC classification number: C07K14/59 ,  A61K38/00

Abstract: Preparations including recombinant FSH (rFSH).