公开(公告)号：US20230073007A1

公开(公告)日：2023-03-09

申请号：US17782416

申请日：2020-12-02

Applicant: OPTOLANE TECHNOLOGIES INC.

Inventor： Seung-Shick SHIN ,  Do young LEE ,  Seong-Min SEO ,  Kyung-Hak CHOI ,  Jae-Chul PYUN

IPC: G01N33/543 ,  C07K16/42 ,  G01N33/68

Abstract: The present invention relates to a switching binder binding to an antigen-binding portion of an antibody, a preparation method thereof, and a pharmaceutical composition, an assay kit, and an antigen and antibody assay method, each utilizing the same. A switching binder according to an embodiment of the present invention includes an amino acid sequence selected from framework regions of a heavy chain or a light chain, which constitutes an antigen-binding portion of an antibody, wherein the amino acid sequence includes, in addition to the heavy chain or the light chain, a first antibody-binding portion or a second antibody-binding portion that binds to a framework region of a heavy chain or a light chain, which constitutes the antigen-binding portion, the amino acid sequence being able to bind specifically to the antigen-binding portion of the antibody and then be separated from the framework region when a target antigen is provided.