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公开(公告)号：US11377469B2
公开(公告)日：2022-07-05
申请号：US16760380
申请日：2018-11-02
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Erica L. Jackson , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya
IPC分类号： C07H19/23 , A61P35/00 , A61K31/706 , C07H19/056 , A61K31/7064 , A61K45/06
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11325938B2
公开(公告)日：2022-05-10
申请号：US17078567
申请日：2020-10-23
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya , Brian R. Blank , Yosup Rew , Kejia Wu , Liusheng Zhu , Johnny Pham , Hiroyuki Kawai
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11124537B2
公开(公告)日：2021-09-21
申请号：US16065626
申请日：2016-12-22
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Haiying Zhou , Minna Delarae Balbas , Valeria R. Fantin
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US11110103B2
公开(公告)日：2021-09-07
申请号：US16065625
申请日：2016-12-22
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Haiying Zhou , Minna Delarae Balbas , Valeria R. Fantin
IPC分类号： C07J41/00 , A61K31/56 , A61K31/58 , A61K31/567 , A61K45/06 , C07J1/00 , C07J21/00 , C07J43/00
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US11807658B2
公开(公告)日：2023-11-07
申请号：US17697318
申请日：2022-03-17
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya , Brian R. Blank , Yosup Rew , Kejia Wu , Liusheng Zhu , Johnny Pham , Hiroyuki Kawai
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11530236B2
公开(公告)日：2022-12-20
申请号：US17083871
申请日：2020-10-29
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya , Brian R. Blank , Yosup Rew , Kejia Wu , Liusheng Zhu , Johnny Pham , Hiroyuki Kawai , Chien-Hung Yeh
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11028120B2
公开(公告)日：2021-06-08
申请号：US17114993
申请日：2020-12-08
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya , Brian R. Blank , Yosup Rew , Kejia Wu , Liusheng Zhu , Johnny Pham , Hiroyuki Kawai , Chien-Hung Yeh
IPC分类号： C07H19/23
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US10472387B2
公开(公告)日：2019-11-12
申请号：US16365422
申请日：2019-03-26
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US12018043B2
公开(公告)日：2024-06-25
申请号：US18051125
申请日：2022-10-31
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Daqing Sun , Qiuping Ye , Jared Moore , Tatiana Zavorotinskaya , Brian R. Blank , Yosup Rew , Kejia Wu , Liusheng Zhu , Johnny Pham , Hiroyuki Kawai , Chien-Hung Yeh
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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公开(公告)号：US11576922B2
公开(公告)日：2023-02-14
申请号：US17404497
申请日：2021-08-17
发明人： Xiaohui Du , John Eksterowicz , Valeria R. Fantin , Erica L. Jackson , Daqing Sun , Qiuping Ye , Jared Moore
IPC分类号： A61K31/675 , C07F9/6558
摘要： Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.
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