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公开(公告)号：US11124537B2
公开(公告)日：2021-09-21
申请号：US16065626
申请日：2016-12-22
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Haiying Zhou , Minna Delarae Balbas , Valeria R. Fantin
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US11110103B2
公开(公告)日：2021-09-07
申请号：US16065625
申请日：2016-12-22
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Haiying Zhou , Minna Delarae Balbas , Valeria R. Fantin
IPC分类号： C07J41/00 , A61K31/56 , A61K31/58 , A61K31/567 , A61K45/06 , C07J1/00 , C07J21/00 , C07J43/00
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US10472387B2
公开(公告)日：2019-11-12
申请号：US16365422
申请日：2019-03-26
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US11208432B2
公开(公告)日：2021-12-28
申请号：US16065627
申请日：2016-12-22
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Haiying Zhou , Minna Delarae Balbas , Valeria R. Fantin
IPC分类号： C07J1/00 , A61P5/44 , A61P5/46 , A61P35/00 , C07J17/00 , C07J41/00 , C07J43/00 , A61K45/06 , C07K16/28
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer and hypercortisolism.
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公开(公告)号：US10723759B2
公开(公告)日：2020-07-28
申请号：US16562204
申请日：2019-09-05
发明人： Daqing Sun , Lawrence R. McGee , Xiaohui Du , Liusheng Zhu , Xuelei Yan , Yosup Rew , John Eksterowicz , Julio C. Medina , Valeria R. Fantin , Haiying Zhou , Minna Delarae Balbas
IPC分类号： A61P35/00 , C07J41/00 , C07J17/00 , C07J43/00 , A61P5/46 , C07J21/00 , C07J31/00 , C07J71/00
摘要： The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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