公开(公告)号：US20230331640A1

公开(公告)日：2023-10-19

申请号：US18337623

申请日：2023-06-20

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi SHIRAKAMI ,  Hayato IKEDA ,  Yasukazu KANAI ,  Eku SHIMOSEGAWA ,  Jun HATAZAWA ,  Tadashi WATABE ,  Kazuko KANEDA

IPC: C07B59/00 ,  C07F13/00 ,  C07F5/02

CPC classification number: C07B59/001 ,  C07F13/00 ,  C07B59/004 ,  C07F5/025 ,  C07F13/005 ,  C07B2200/05

Abstract: The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

公开(公告)号：US20200369578A1

公开(公告)日：2020-11-26

申请号：US16636236

申请日：2018-08-03

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi SHIRAKAMI ,  Hayato IKEDA ,  Yasukazu KANAI ,  Eku SHIMOSEGAWA ,  Jun HATAZAWA ,  Tadashi WATABE ,  Kazuko KANEDA

IPC: C07B59/00 ,  C07F13/00

Abstract: The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

公开(公告)号：US20230302169A1

公开(公告)日：2023-09-28

申请号：US18317224

申请日：2023-05-15

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi SHIRAKAMI ,  Tadashi WATABE ,  Kazuko KANEDA ,  Eku SHIMOSEGAWA ,  Atsushi SHINOHARA ,  Jun HATAZAWA

IPC: A61K51/12 ,  A61K47/22

CPC classification number: A61K51/121 ,  A61K47/22

Abstract: The invention provides a method for producing a solution containing 211At− (astatide ion) at a high radiochemical purity by using 211At obtained by a nuclear reaction as a starting material, including a step of adding a reducing agent to a solution containing an impurity derived from 211At. The invention also provides a solution containing 211At− (astatide ion) at a radiochemical purity of not less than 30%.