公开(公告)号：US20230310561A1

公开(公告)日：2023-10-05

申请号：US18023573

申请日：2021-09-07

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Shuko TAKEDA ,  Hiroki HAYASHI

IPC: A61K39/00 ,  A61P25/28

CPC classification number: A61K39/0005 ,  A61P25/28 ,  A61K2039/6031 ,  A61K2039/575

Abstract: The present invention provides an immunogenic composition comprising an antigenic peptide and a carrier protein, wherein the antigenic peptide is capable of eliciting production of an antibody against a phosphorylated tau protein and is a human tau protein fragment containing (1) YSpSPGpSPG (SEQ ID NO: 2), (2) AKpSpTPpTAE (SEQ ID NO: 5), (3) AKpSpTPTAE (SEQ ID NO: 31), (4) AKpSTPpTAE (SEQ ID NO: 32), (5) AKSpTPpTAE (SEQ ID NO: 33), or (6) IVpYKpSPV (SEQ ID NO: 24).

公开(公告)号：US20230141614A1

公开(公告)日：2023-05-11

申请号：US17913066

申请日：2021-02-12

Applicant: OSAKA UNIVERSITY

Inventor： Shuko TAKEDA ,  Ryuichi MORISHITA

IPC: A61B5/00 ,  A61B3/113

CPC classification number: A61B5/4088 ,  A61B3/113 ,  A61B5/7445

Abstract: A cognitive impairment diagnostic device includes: an obtainer that obtains a distribution map representing a distribution of gaze points of a subject on a movie for cognitive assessment; and a diagnoser. The movie for cognitive assessment includes, in time order: a first movie including a first region including an image for encoding displayed in a visually enhanced manner, and a plurality of second regions including normal images displayed without being enhanced; and an assessment movie including a third region including an assessment image similar to the image for encoding and displayed at a same position as the image for encoding without being visually enhanced, and the second regions. The diagnoser calculates, in a distribution map on the assessment movie, a percentage of fixation duration for which the third region is focused on, and makes diagnosis of suspected memory impairment when the percentage of fixation duration is lower than a threshold.