公开(公告)号：US20210000988A1

公开(公告)日：2021-01-07

申请号：US16979346

申请日：2019-02-22

Applicant: OSAKA UNIVERSITY

Inventor： Koichi FUKASE ,  Atsushi SHINOHARA ,  Yoshikatsu KANAI ,  Kazuya KABAYAMA ,  Kazuko KANEDA ,  Zijian ZHANG ,  Jun HATAZAWA ,  Yoshifumi SHIRAKAMI ,  Atsushi SHIMOYAMA ,  Yoshiyuki MANABE

IPC: A61K51/04 ,  A61P35/00

Abstract: To develop a compound which is highly accumulated in cancer cells and capable of emitting an α-ray and provide a pharmaceutical composition for cancer treatment including the compound.
A pharmaceutical composition for cancer treatment including a compound having a structure in which 211At is introduced as a substituent into an amino acid derivative having an affinity with an amino acid transporter LAT1 or a pharmaceutically acceptable salt of the compound.

公开(公告)号：US20210210244A1

公开(公告)日：2021-07-08

申请号：US16980617

申请日：2019-03-01

Applicant: OSAKA UNIVERSITY

Inventor： Atsushi SHINOHARA ,  Atsushi TOYOSHIMA ,  Zijian ZHANG ,  Akimitsu KANDA ,  Soichiro ICHIMURA

IPC: G21G1/00 ,  G21G4/08

Abstract: There is provided a radionuclide manufacturing system, a computer-readable storage medium storing a radionuclide manufacturing program, a radionuclide manufacturing method, and a terminal device for more stably manufacturing a radionuclide.
A radionuclide manufacturing system includes: a heating unit configured to internally house a target holding a radionuclide; a gas supply unit; an adsorption unit configured to adsorb the radionuclide; a solvent supply unit; a storage unit configured to store a predetermined instruction; and a control unit configured to control the heating unit to heat the target at a temperature at which the radionuclide held in the target is allowed to volatilize, to control the gas supply unit to supply the carrier gas to the heating unit in order to transport the radionuclide volatilized in the heating unit to the adsorption unit, and to control the solvent supply unit in order to supply a solvent for eluting the radionuclide adsorbed to the adsorption unit to the adsorption unit based on the instruction.

公开(公告)号：US20220387636A1

公开(公告)日：2022-12-08

申请号：US17882708

申请日：2022-08-08

Applicant: OSAKA UNIVERSITY

Inventor： Koichi FUKASE ,  Atsushi SHINOHARA ,  Yoshikatsu KANAI ,  Kazuya KABAYAMA ,  Kazuko KANEDA ,  Zijian ZHANG ,  Jun HATAZAWA ,  Yoshifumi SHIRAKAMI ,  Atsushi SHIMOYAMA ,  Yoshiyuki MANABE

IPC: A61K51/04

Abstract: To develop a compound which is highly accumulated in cancer cells and capable of emitting an α-ray and provide a pharmaceutical composition for cancer treatment including the compound.
A pharmaceutical composition for cancer treatment including a compound having a structure in which 211At is introduced as a substituent into an amino acid derivative having an affinity with an amino acid transporter LAT1 or a pharmaceutically acceptable salt of the compound.