公开(公告)号：US20250014771A1

公开(公告)日：2025-01-09

申请号：US18709397

申请日：2022-11-07

Applicant: Westinghouse Electric Company LLC ,  University of Pittsburgh - of the Commonwealth System of Higher Education

Inventor： Michael D. Heibel ,  Brian J. LoPresti ,  Thomas V. Congedo

IPC: G21G1/12 ,  G21G1/00

Abstract: Devices, systems, and methods to produce Ac-225 from Ra-226 using gamma-radiation generator are disclosed herein. The gamma radiation generator can utilize an electronic neutron generator or a nuclear reactor to produce high energy prompt-capture gamma-radiation. The Ra-226 is irradiated by the gamma radiation to produce Ra-225, which decays to produce Ac-225. The method of using electronic neutron generator and an irradiation target material such as Gd-157 to produce high energy gamma radiation without using a continuously decaying radioisotope such as Co-60 could significantly reduce the cost and increase the safety associated with the production of high energy gamma radiation and Ac-225.

公开(公告)号：US20240347222A1

公开(公告)日：2024-10-17

申请号：US18644443

申请日：2024-04-24

Applicant: TerraPower, LLC

Inventor： Ken Czerwinski ,  Joshua C. Walter ,  Christopher Dunckley

IPC: G21G1/02 ,  B01D11/02 ,  B01D11/04 ,  B01D15/40 ,  G21C19/42 ,  G21G1/00 ,  G21G1/08

CPC classification number: G21G1/02 ,  B01D11/0203 ,  B01D11/0403 ,  B01D15/40 ,  G21C19/42 ,  G21G1/08 ,  B01D2215/027 ,  G21G2001/0036 ,  G21G2001/0094 ,  Y02P20/54

Abstract: Targetry coupled separation refers to enhancing the production of a predetermined radiation product through the selection of a target (including selection of the target material and the material's physical structure) and separation chemistry in order to optimize the recovery of the predetermined radiation product. This disclosure describes systems and methods for creating (through irradiation) and removing one or more desired radioisotopes from a target and further describes systems and methods that allow the same target to undergo multiple irradiations and separation operations without damage to the target. In contrast with the prior art that requires complete dissolution or destruction of a target before recovery of any irradiation products, the repeated reuse of the same physical target allowed by targetry coupled separation represents a significant increase in efficiency and decrease in cost over the prior art.

公开(公告)号：US20240339237A1

公开(公告)日：2024-10-10

申请号：US18618279

申请日：2024-03-27

Applicant: AdvanCell Isotopes Pty Limited

Inventor： Julian Frederick KELLY

IPC: G21G4/08 ,  G21G1/00

CPC classification number: G21G4/08 ,  G21G2001/0094

Abstract: The present disclosure generally relates to materials, processes, generators, and/or systems, for generating radioisotope. The present disclosure also generally relates to ceramic materials comprising radioisotope suitable for use in a radioisotope generator. The present disclosure also generally relates to processes, generators and/or systems, for producing and capturing radioisotope. The present disclosure also generally relates to the preparation of radioisotope solutions for use in radiopharmacy and/or other clinical applications.

公开(公告)号：US20240339235A1

公开(公告)日：2024-10-10

申请号：US18745896

申请日：2024-06-17

Applicant: Curium US LLC

Inventor： Brian Regna ,  Allan Casciola ,  Lauren Radford ,  Shaun Loveless ,  David Pipes ,  William Uhland ,  Craig Brunkhorst

IPC: G21G1/00 ,  A61K51/04 ,  C01G3/00 ,  G21G1/10 ,  G21G4/08

CPC classification number: G21G1/001 ,  A61K51/0482 ,  C01G3/003 ,  G21G1/10 ,  G21G4/08 ,  G21G2001/0094

Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

公开(公告)号：US20240339233A1

公开(公告)日：2024-10-10

申请号：US18397202

申请日：2023-12-27

Applicant: CVF International LLC

Inventor： Pavel MOSEEV ,  Aleksandr KLACHKOV ,  Roman TERTYCHNYY ,  Aleksandr KHASIN

IPC: G21G1/00 ,  G21G1/06 ,  G21G4/02

CPC classification number: G21G1/001 ,  G21G1/06 ,  G21G4/02 ,  G21G2001/0094

Abstract: Methods and systems are provided for cyclical enrichment, especially of rare earth elements and isotopes. A tube, or ampule, optionally with one crucible, or with two coaxially opposite crucibles in fluid communication, is used to hold a source material in vacuum and irradiate the source material to enrich it with product material. Following the irradiation of the source substance (e.g., Yb, enriched with 176Yb) to yield the product substance (e.g., 177Lu), the mixture may be sublimated to remove most of the source substance and concentrate the product material, e.g., by heating the lower part and cooling the upper part of the tube, to condense sublimated source material at the top of the tube. Consecutively, the concentrated product substance may be purified, while the solidified source structure may be reused in irradiation/sublimation cycles to further enrich and concentrate the product material.

公开(公告)号：US20240331888A1

公开(公告)日：2024-10-03

申请号：US18680372

申请日：2024-05-31

Applicant: Sciencons AS

Inventor： Roy H. Larsen

IPC: G21G1/00 ,  G21F5/015 ,  G21F5/018

CPC classification number: G21G1/0005 ,  G21F5/015 ,  G21F5/018

Abstract: The present invention relates to assemblies and method for obtaining a container comprising 212Pb on the walls obtained from a 212Pb precursor isotope source. The invention provides an improved system and method for producing 212Pb in high purity without the need for processing, with high yields, and which safely and efficiently can be transported to the locations where it is to be used.

公开(公告)号：US20240233972A9

公开(公告)日：2024-07-11

申请号：US17969060

申请日：2022-10-19

Applicant: BATTELLE SAVANNAH RIVER ALLIANCE, LLC

Inventor： BRENDA L. GARCIA-DIAZ ,  CHRISTOPHER S. DANDENEAU ,  DALE A. HITCHCOCK ,  DAVE BABINEAU ,  ROBERT SINDELAR ,  HECTOR COLON-MERCADO ,  GEORGE K. LARSEN

IPC: G21G1/00 ,  C25B1/02 ,  G21G1/02

CPC classification number: G21G1/001 ,  C25B1/02 ,  G21G1/02 ,  G21G2001/0094

Abstract: Disclosed are galvanic cells and methods for treating a molten salt by use of the galvanic cells. The galvanic cell can provide anti-corrosion treatment and improved corrosion resistance via electrochemical and chemical reactions involving a corrosive impurity in a molten salt. Reaction products of the chemical and electrochemical reactions include hydrogen gas that can carry hydrogen isotopes evolved in the molten salt. The system can also include removal of the hydrogen gas from the molten salt and separation and recovery of tritium contained therein.

公开(公告)号：US11996209B2

公开(公告)日：2024-05-28

申请号：US17269588

申请日：2019-08-22

Applicant: JUBILANT DRAXIMAGE INC.

Inventor： Robert William Riddoch ,  Etienne Lefort ,  Paul Donnelly ,  Riccardo Santopietro ,  Thomas Allen Moore

IPC: G21G1/00 ,  A61M5/142

CPC classification number: G21G1/0005 ,  A61M5/142 ,  G21G1/001 ,  A61M2205/70 ,  G21G2001/0031

Abstract: Disclosed herein are rubidium elution systems comprising a primary assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump system, a sensor, a tubing circuit, at least one valve, and a computer; and a dose calibrator outside the primary assembly. The system may have an interface for configuring the dose calibrator, and a locking means for preventing access to the interface and reconfigurations of its parameters. Moreover, the dose calibrator may be in electronic communication with the computer of the system. Furthermore, the electronic communication can be embodied with an electronic cable having a breakaway connector. Also, the dose calibrator may be positioned on a mobile platform.

公开(公告)号：US11986815B2

公开(公告)日：2024-05-21

申请号：US17413146

申请日：2019-12-10

Applicant: SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES ET GÉNIE S.E.C.

Inventor： Brigitte Guerin ,  Sebastien Tremblay ,  Samia Ait-Mohand ,  Aiman H. Alnahwi

IPC: B01J47/026 ,  A61B6/03 ,  A61K51/08 ,  B01J39/26 ,  G21G1/00 ,  G21G1/10

CPC classification number: B01J47/026 ,  A61K51/083 ,  B01J39/26 ,  A61B6/037 ,  G21G2001/0021 ,  G21G1/10

Abstract: The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of 68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of 68Ga. In additional embodiments, the process is implemented by an automated system.

公开(公告)号：US20240145110A1

公开(公告)日：2024-05-02

申请号：US18542674

申请日：2023-12-16

Applicant: Jubilant Draximage Inc.

Inventor： Robert William Riddoch

IPC: G21G1/00 ,  G21G4/08

CPC classification number: G21G1/00 ,  G21G1/0005 ,  G21G4/08 ,  A61K51/00

Abstract: The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.