公开(公告)号：US20210205234A1

公开(公告)日：2021-07-08

申请号：US17163871

申请日：2021-02-01

申请人： OSAKA UNIVERSITY ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

发明人： Hiroyuki TANAKA ,  Kiyoshi OKADA ,  Hideki YOSHIKAWA ,  Koji SUZUKI ,  Mitsuhiro EBARA

IPC分类号： A61K9/70 ,  A61K47/34 ,  A61K47/36 ,  A61K31/714 ,  A61K35/36 ,  A61K45/00 ,  A61K38/18 ,  A61P25/02 ,  A61K47/32

摘要： A sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet including a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.

公开(公告)号：US20190083415A1

公开(公告)日：2019-03-21

申请号：US16082594

申请日：2017-03-06

申请人： OSAKA UNIVERSITY ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

发明人： Hiroyuki TANAKA ,  Kiyoshi OKADA ,  Hideki YOSHIKAWA ,  Koji SUZUKI ,  Mitsuhiro EBARA

IPC分类号： A61K9/70 ,  A61K31/714 ,  A61K35/36 ,  A61K38/18 ,  A61K47/34 ,  A61K47/32 ,  A61K47/36 ,  A61P25/02

摘要： Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.